By a News Reporter-Staff News Editor at Science Letter -- A new study on Enterovirus is now available. According to news reporting out of Jyvaskyla, Finland, by NewsRx editors, research stated, "Development of precise protocols for accurate site-specific conjugation of monodisperse inorganic nanoparticles to biological material is one of the challenges in contemporary bionanoscience and nanomedicine. We report here a successful site-specific covalent conjugation of functionalized atomically monodisperse gold clusters with 1.5-nm metal cores to viral surfaces."
Our news journalists obtained a quote from the research from the University of Jyvaskyla, "Water-soluble Au-102(para-mercaptobenzoic acid)(44) clusters, functionalized by maleimide linkers to target cysteines of viral capsid proteins, were synthesized and conjugated to enteroviruses echovirus 1 and coxsackievirus B3. Quantitative analysis of transmission electron microscopy images and the known virus structures showed high affinity and mutual ordering of the bound gold clusters on the viral surface and a clear correlation between the clusters and the targeted cysteine sites close to the viral surface. Infectivity of the viruses was not compromised by loading of several tens of gold clusters per virus."
According to the news editors, the research concluded: "These advances allow for future investigations of the structure-function relations of enteroviruses and enterovirus-related virus-like particles, including their entry mechanisms into cells and uncoating in cellular endosomes."
For more information on this research see: Site-specific targeting of enterovirus capsid by functionalized monodisperse gold nanoclusters. Proceedings of the National Academy of Sciences of the United States of America, 2014;111(4):1277-1281. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
Our news journalists report that additional information may be obtained by contacting V. Marjomakia, University of Jyvaskyla, Nanosci Center, FI-40014 Jyvaskyla, Finland. Additional authors for this research include T. Lahtinen, M. Martikainen, J. Koivisto, S. Malola, K. Salorinne, M. Pettersson and H. Hakkinen (see also Enterovirus).
Keywords for this news article include: Viral, Europe, Virion, Finland, Virology, Jyvaskyla, Enterovirus, RNA Viruses, Nucleocapsid, Picornaviridae
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