The patent's assignee is
News editors obtained the following quote from the background information supplied by the inventors: "Superparamagnetic iron oxide nanoparticles have been explored for uses in various medical applications, including, for example, MRI, hyperthermia therapy, and drug release systems. In MRI applications, superparamagnetic iron oxide nanoparticles have been investigated as contract agents and breast tumor imaging. In one study, nanoparticles that were modified with tumor targeting ligands (e.g., breast cancer cell surface receptor urokinase-type plasminogen activator) accumulated in mice breast tumors and generated strong contrast for imaging by clinical MRI (3 Tesla). In another study, targeted nanoparticles were used to detect circulating breast cancer cells in the blood, again using a mouse model.
"In hyperthermia therapy, under median-level alternating magnetic field (AMF), magnetic nanoparticles can generate heat to induce breast cancer cell apoptosis. In one study, thermoablative therapy of breast cancer in mice was performed using antibody (mAb)-linked iron oxide nanoparticles. The magnetic nanoparticles were injected intravenously. The nanoparticles targeted human breast cancer xenografts in the mice, resulting in a delay in tumor growth after the AMF was applied.
"Magnetic field drug release delivery systems have been investigated in the form of iron oxide loaded gels (e.g., gelatin, PVA), scaffolds, microbeads, composite membranes, nanoemulsions, silica nanocapsules or polymer nanoparticles. In one study, magnetic nanoparticles were bound with a chemotherapy drug and tested for targeted chemotherapy in a rabbit liver tumor model. Magnetic particles have also been investigated for both imaging and drug delivery in prostate cancer.
"There is concern that pure iron oxide leads to acute toxicity. Further, due to anisotropic bipolar attraction, iron oxide nanoparticles may aggregate. The nanoparticles systems described above are based on encapsulated iron oxide nanoparticles to combat or mitigate aggregation and toxicity. The nanoparticles and any associated drug may be dispersed in oil/water and encapsulated by a multilayer polymer/liposome shell. However, heat conduction is relatively difficult with the multilayer shell as heat generated by the iron oxide must be transferred through the relatively low conductivity water/oil phase and then transferred to and through the polymer shell.
"Accordingly room for improvement remains in the field of iron oxide nanoparticle formation and use, wherein the iron oxide particles may be more biocompatible, yet still transmit heat into surrounding matter."
As a supplement to the background information on this patent application, VerticalNews correspondents also obtained the inventors' summary information for this patent application: "An aspect of the present disclosure relates to a method of forming magnetic calcium phosphate particles. The method may include preparing a calcium hydroxide solution and filtering the calcium hydroxide solution through a filter. The method may also include forming an iron chloride solution and combining the iron chloride solution with the filtered calcium hydroxide solution. In addition, the method may include combining a phosphoric acid solution (without or with chitosan) with the combined solutions of iron chloride and calcium hydroxide and forming a mixture including particles comprising iron oxide and calcium phosphate.
"Another aspect of the present disclosure relates to a preparation of magnetic calcium phosphate particles. The particles comprise iron oxide and calcium phosphate. Furthermore, a polysaccharide coating such as chitosan may be present on the particles. The particles are less than or equal to 1,000 nm, are magnetic, and exhibit a positive charge in the range of lmVolts to 60 mVolts.
"A further aspect of the present disclosure relates to a method of treating a disease, condition or associative disorder including administering an effective amount of magnetic calcium phosphate particles to a patient/animal. And yet a further aspect of the present disclosure relates to a method of combining a sample including the biological composition with magnetic calcium phosphate particles, wherein the magnetic calcium phosphate particles bind with the biological composition; and analyzing the biological composition.
BRIEF DESCRIPTION OF THE DRAWINGS
"The above-mentioned and other features of this disclosure, and the manner of attaining them, will become more apparent and better understood by reference to the following description of embodiments described herein taken in conjunction with the accompanying drawings, wherein:
"FIG. 1 illustrates a general method of preparing magnetic calcium phosphate nanoparticles;
"FIG. 2 illustrates a method of preparing magnetic calcium phosphate nanoparticles from solutions of calcium hydroxide, iron (II) chloride, iron (III) chloride, and phosphoric acid and chitosan;
"FIG. 3 illustrates a method of coating magnetic calcium phosphate nanoparticles with chitosan;
"FIGS. 4a, 4b and 4c illustrate the relatively strong magnetism observed of the fabricated magnetic calcium phosphate nanoparticles, having the ability to move along with the magnets, be arrested by the magnets and be attracted to the surface of magnets.
"FIG. 5 illustrates a method of treatment by administering, targeting and heating magnetic calcium phosphate nanoparticles;
"FIG. 6 illustrates the measured effective particle diameter of a sample of magnetic calcium phosphate nanoparticles;
"FIG. 7 illustrates the zeta potential measurement of the magnetic calcium phosphate nanoparticles;
"FIG. 8 illustrates the measured effective diameter of another sample of magnetic calcium nanoparticles;
"FIG. 9 illustrates an SEM image of the prepared magnetic calcium phosphate nanoparticles at a 1 .mu.m scale taken under 50.00 K magnification;
"FIGS. 10a and 10b illustrate FTIR spectrums for 1) magnetic calcium phosphate (A) synthesized herein, 2) pure iron oxide particles (B), and 3) pure hydroxyapatite nanoparticles (C); and
"FIG. 11 illustrates the increase temperature over time for 10% by weight and 15% by weight suspensions of the magnetic calcium phosphate particles in water upon application of alternating current through the coil."
For additional information on this patent application, see: CHENG, Xingguo; Ni, Qingwen;
Keywords for this news article include: Anions, Therapy, Alkalies, Chemistry, Chlorides, Nanoparticle, Nanotechnology, Phosphoric Acids, Calcium Compounds, Calcium Hydroxide, Hydrochloric Acid, Calcium Phosphates, Inorganic Chemicals, Phosphorus Compounds, Emerging Technologies,
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