By a News Reporter-Staff News Editor at Science Letter -- Current study results on Science have been published. According to news reporting out of Oxford, United Kingdom, by NewsRx editors, research stated, "The movement of molecules inside living cells is a fundamental feature of biological processes. The ability to both observe and analyse the details of molecular diffusion in vivo at the single-molecule and single-cell level can add significant insight into understanding molecular architectures of diffusing molecules and the nanoscale environment in which the molecules diffuse."
Our news journalists obtained a quote from the research from Oxford University, "The tool of choice for monitoring dynamic molecular localization in live cells is fluorescence microscopy, especially so combining total internal reflection fluorescence with the use of fluorescent protein (FP) reporters in offering exceptional imaging contrast for dynamic processes in the cell membrane under relatively physiological conditions compared with competing single-molecule techniques. There exist several different complex modes of diffusion, and discriminating these from each other is challenging at the molecular level owing to underlying stochastic behaviour. Analysis is traditionally performed using mean square displacements of tracked particles; however, this generally requires more data points than is typical for single FP tracks owing to photophysical instability. Presented here is a novel approach allowing robust Bayesian ranking of diffusion processes to discriminate multiple complex modes probabilistically."
According to the news editors, the research concluded: "It is a computational approach that biologists can use to understand single-molecule features in live cells."
For more information on this research see: Inferring diffusion in single live cells at the single-molecule level. Philosophical Transactions, 2013;368(1611):20120029 (see also Science).
Our news journalists report that additional information may be obtained by contacting A. Robson, Clarendon Laboratory, Dept. of Physics, Oxford University, Parks Road, Oxford OX1 3PU, UK. Additional authors for this research include K. Burrage and M.C Leake.
Keywords for this news article include: Oxford, Europe, Science, United Kingdom.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC