By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Science. According to news originating from Cambridge, Massachusetts, by NewsRx correspondents, research stated, "The miniaturization of bioelectronic intracellular probes with a wide dynamic frequency range can open up opportunities to study biological structures inaccessible by existing methods in a minimally invasive manner. Here, we report the design, fabrication, and demonstration of intracellular bioelectronic devices with probe sizes less than 10 nm."
Our news journalists obtained a quote from the research from Harvard University, "The devices are based on a nanowire-nanotube heterostructure in which a nanowire field-effect transistor detector is synthetically integrated with a nanotube cellular probe. Sub-10-nm nanotube probes were realized by a two-step selective etching approach that reduces the diameter of the nanotube free-end while maintaining a larger diameter at the nanowire detector necessary for mechanical strength and electrical sensitivity. Quasistatic water-gate measurements demonstrated selective device response to solution inside the nanotube, and pulsed measurements together with numerical simulations confirmed the capability to record fast electrophysiological signals. Systematic studies of the probe bandwidth in different ionic concentration solutions revealed the underlying mechanism governing the time response. In addition, the bandwidth effect of phospholipid coatings, which are important for intracellular recording, was investigated and modeled. The robustness of these sub-10-nm bioelectronics probes for intracellular interrogation was verified by optical imaging and recording the transmembrane resting potential of HL-1 cells."
According to the news editors, the research concluded: "These ultrasmall bioelectronic probes enable direct detection of cellular electrical activity with highest spatial resolution achieved to date, and with further integration into larger chip arrays could provide a unique platform for ultra-high-resolution mapping of activity in neural networks and other systems."
For more information on this research see: Sub-10-nm intracellular bioelectronic probes from nanowire-nanotube heterostructures. Proceedings of the National Academy of Sciences of the United States of America, 2014;111(4):1259-1264. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
The news correspondents report that additional information may be obtained from T.M. Fu, Harvard University, Sch Engn & Appl Sci, Cambridge, MA 02138, United States. Additional authors for this research include X.J. Duan, Z. Jiang, X.C. Dai, P. Xie, Z.G. Cheng and C.M. Lieber (see also Science).
Keywords for this news article include: Science, Cambridge, Massachusetts, United States, North and Central America
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