By a News Reporter-Staff News Editor at Science Letter -- A new study on Neuroglia is now available. According to news reporting from Seoul, South Korea, by NewsRx journalists, research stated, "70 mu m-thick porous Si (PSi) layer with the pore size of 11.1 +/- 7.6 nm was formed on an 8-in. Si wafer via an anodization process for the microfabrication of a microelectrode to record neural signals."
The news correspondents obtained a quote from the research from the Seoul National University of Science and Technology, "To reduce host tissue responses to the microelectrode and achieve a stable neural interface, water-soluble dexamethesone (Dex) was loaded into the PSi via incubation with the drug solution overnight. After the drug loading process, the pore size of PSi reduced to 4.7 +/- 2.6 nm on the basis of scanning electron microscopic (SEM) images, while its wettability was remarkably enhanced. Fluorescence images demonstrated that Dex was loaded into the porous structure of the PSi. Degradation rate of the PSi was investigated by incubation in distilled water for 21 days. Moreover, the drug release profile of the Dex-loaded PSi was a combination of an initial burst release and subsequent sustained release. To evaluate cellular responses to the drug release from the PSi, primary astrocytes were seeded on the surface of samples. After 2 days of culture, the Dex-loaded PSi could not only moderately prevent astrocyte adhesion in comparison with Si, but also more effectively suppress the activation of primary astrocytes than unloaded PSi due to the drug release."
According to the news reporters, the research concluded: "Therefore, it might be an effective method to reduce host tissue responses and stabilize the quality of the recorded neural signal by means of loading drugs into the PSi component of the microelectrode."
For more information on this research see: Drug release from porous silicon for stable neural interface. Applied Surface Science, 2014;292():843-851. Applied Surface Science can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Applied Surface Science - www.elsevier.com/wps/product/cws_home/505669)
Our news journalists report that additional information may be obtained by contacting T. Sun, Seoul Natl Univ Sci & Technol, Dept. of Mech & Automot Engn, Seoul, South Korea. Additional authors for this research include W.M. Tsang and W.T. Park (see also Neuroglia).
Keywords for this news article include: Asia, Seoul, Neuroglia, Astrocytes, South Korea, Nanotechnology, Porous Silicon, Emerging Technologies
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