News Column

UC San Diego Extension Workshop to Examine Science and Practice of "Mammalian Fermentation"

March 4, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Cultivated mammalian cells, known as "mammalian fermentation," have become the dominant system for the production of recombinant proteins for clinical applications. To bring these products to market involves significant effort and continuous advances in process development. These efforts aim to increase the level of product understanding and identify those key quality attributes that help in reproducing product batches (see also UC San Diego Extension).

Large-scale cell culture operations have improved tremendously in recent decades due to increased process understanding. Improvements in safety profiles have also been made with overlapping and redundant controls to prevent, detect, and remove potential adventitious agents. Process understanding is ultimately reduced to practice through a system of measurement, monitoring, modeling, and control for each unit operation in the bioprocess.

To address the current state of science and practice in this field, UC San Diego Extension will co-present a three-day course titled "Mammalian Fermentation Workshop," April 30 through May 2, at the UC San Diego campus.

Developed in partnership with UC San Diego's Center for Continuing Education in Biosciences (CCE-BIO), part of the Biological Sciences Division, the program features both UC San Diego faculty members and industry-based speakers.

"Today's sophisticated pharmaceutical drugs are not just chemicals, but also biological agents, such as proteins and antibodies," said Hugo Villar, director of science and technology at UC San Diego Extension. "Their production requires the use of cell culture and fermentation techniques that have become extremely important in the biotechnology and pharmaceutical industries, and it requires the optimization of a number of complex variables."

Villar added, "These new therapeutic agents require new means of production, completely unlike those used to produce traditional chemicals as drugs and they are subject to their own set of regulatory requirements."

Open to the public, the two-unit workshop is designed for professionals with a broad range of industry skills and experiences who wish to expand on their current knowledge and improve their ability to problem-solve. Having a rudimentary understanding of microbial or mammalian cell culture processes is advised.

Keywords for this news article include: Chemicals, Chemistry, UC San Diego Extension.

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Source: Life Science Weekly

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