Melanoma is the deadliest form of skin cancer. For their cross-disciplinary melanoma research proposals, two teams of TAU scientists and doctors received a total of
How cancer cells move to the brain
Prof. Satchi-Fainaro and her colleagues - Dr.
"The whole field of nanomedicines for cancer is based on the fact that nanometric-size drugs (around 10-200 nanometers) are too large to leak out from normal blood vessels and harm healthy organs," said Prof. Satchi-Fainaro. "On the other hand, tumor blood vessels are incredibly leaky, so the nanomedicines can selectively exit from those blood vessels and accumulate at the tumor mass. Once at the tumor site, the new nanomedicines can inhibit the cross-talk between the melanoma cells and the brain microenvironment. We hope that our novel approach for co-targeting melanoma cells and astrocytes will pave the road for new clinical interventions."
A disarmament proposal for tumor cells
The MRA granted its second Team Science Award of
"Immunotherapy, which has existed for decades, has had slim success rates in melanoma treatment. But now, after new insights and developments over the last 10 years, it has become a hot topic everyone is discussing," said Dr. Markel. "We are focused on the immunology of melanoma - how the immune system reacts to melanoma cells, how melanoma evades the immune system, and defining key processes."
Dr. Markel's team is working directly with melanoma patients who are treated with immunotherapy. "We are taking advantage of our years of unique clinical work, bringing it to the bench for a cutting-edge multi-faceted discovery process," Dr. Markel says.
To date, the MRA, which is the largest private funder of melanoma research, has awarded more than
Keywords for this news article include: Hospital, Treatment, American Friends of
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