By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Nanoparticles. According to news originating from Aracatuba, Brazil, by NewsRx correspondents, research stated, "The aim of this study was to assess the effect of different silver nanoparticles (SN) concentrations on the matrix composition and structure of Candida albicans and Candida glabrata biofilms. Candida biofilms were developed in 6-well microtiter plates during 48 h."
Our news journalists obtained a quote from the research from State University, "After, these biofilms were exposed to 13.5 or 54 ?g SN ml(-1) for 24 h. Then, extracellular matrices were extracted from biofilms and analysed chemically in terms of proteins, carbohydrates and DNA. To investigate the biofilm structure, scanning electron microscopy (SEM) and epifluorescence microscopy were used. SN interfered with the matrix composition of Candida biofilms tested in terms of protein, carbohydrate and DNA, except for the protein content of C. albicans biofilm. By SEM, Candida biofilms treated with SN revealed structural differences, when compared with the control groups. Further, SN showed a trend of agglomeration within the biofilms. Epifluorescence microscopy images suggest that SN induced damage on cell walls of the Candida isolates tested. In general, irrespective of concentration, SN affected the matrix composition and structure of Candida biofilms and these findings may be related to the mechanisms of biocide action of SN. This study reveals new insights about the behaviour of SN when in contact with Candida biofilms."
According to the news editors, the research concluded: "SN may contribute to the development of therapies to prevent or control Candida infections."
For more information on this research see: Silver colloidal nanoparticles: effect on matrix composition and structure of Candida albicans and Candida glabrata biofilms. Journal of Applied Microbiology, 2013;114(4):1175-83. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Microbiology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2672)
The news correspondents report that additional information may be obtained from D.R. Monteiro, Dept. of Dental Materials and Prosthodontics, Aracatuba Dental School, Univ Estadual Paulista (UNESP), Aracatuba, Sao Paulo, Brazil. Additional authors for this research include S. Silva, M. Negri, L.F. Gorup, E.R. de Camargo, R. Oliveira, D.B. Barbosa and M. Henriques (see also Nanoparticles).
Keywords for this news article include: Brazil, Aracatuba, South America, Nanotechnology, Emerging Technologies, Clinical Trials and Studies.
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