By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Neurology. According to news reporting out of Istanbul, Turkey, by NewsRx editors, research stated, "Functional near infrared spectroscopy (fNIRS) is a promising method for monitoring cerebral hemodynamics with a wide range of clinical applications. INIRS signals are contaminated with systemic physiological interferences from both the brain and superficial tissues, resulting in a poor estimation of the task related neuronal activation."
Our news journalists obtained a quote from the research from Istanbul Bilgi University, "In this study, we use the anatomical resolution of functional magnetic resonance imaging (fMRI) to extract scalp and brain vascular signals separately and construct an optically weighted spatial average of the fMRI blood oxygen level-dependent (BOLD) signal for characterizing the scalp signal contribution to fNIRS measurements. We introduce an extended superficial signal regression (ESSR) method for canceling physiology-based systemic interference where the effects of cerebral and superficial systemic interference are treated separately. We apply and validate our method on the optically weighted BOLD signals, which are obtained by projecting the fMRI image onto optical measurement space by use of the optical forward problem. The performance of ESSR method in removing physiological artifacts is compared to i) a global signal regression (GSR) method and ii) a superficial signal regression (SSR) method. The retrieved signals from each method are compared with the neural signals that represent the 'ground truth' brain activation cleaned from cerebral systemic fluctuations. We report significant improvements in the recovery of task induced neural activation with the ESSR method when compared to the other two methods as reflected in the Pearson R2 coefficient and mean square error (MSE) metrics (two tailed paired t-tests, p
According to the news editors, the research concluded: "We conclude that maximizing the overlap between the optical pathlength of superficial and deeper penetration measurements is of crucial importance for accurate recovery of the evoked hemodynamic response in (NIRS recordings."
For more information on this research see: Analysis of task-evoked systemic interference in fNIRS measurements: Insights from fMRI. Neuroimage, 2014;87():490-504. Neuroimage can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Neuroimage - www.elsevier.com/wps/product/cws_home/622925)
Our news journalists report that additional information may be obtained by contacting S.B. Erdogan, Istanbul Bilgi Univ, Dept. of Genet & Bioengn, TR-34060 Istanbul, Turkey. Additional authors for this research include M.A. Yucel and A. Akin (see also Neurology).
Keywords for this news article include: Turkey, Eurasia, Istanbul, Neurology
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