By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Proteins is the subject of a report. According to news reporting originating in Milan, Italy, by NewsRx journalists, research stated, "This study describes the formulation optimization and body-cell distribution and clearance in mice of a dually fluorescent biodegradable poly avidin nanoassembly based on the novel Avidin-Nucleic-Acid-Nano-ASsembly (ANANAS) platform as a potential advancement of classic avidin/biotin-based targeted delivery. The nanoformulation circulates freely in the bloodstream; it is slowly captured by filter organs; it is efficiently deared within 24-48 h, and it is poorly immunogenic."
The news reporters obtained a quote from the research from Institute for Cancer Research and Treatment (IRCCS), "The system displays more favorable properties than its parent monomeric avidin and it is a promising tool for diagnostic purposes for future translational aims, for which free circulation in the bloodstream, safety, multifunctionality and high composition definition are all necessary requirements. In addition, the assembly shows a time-dependent cell penetration capability, suggesting it may also function as a NP-dependent drug delivery tool."
According to the news reporters, the research concluded: "The ease of preparation together with the possibility to fine-tune the surface composition makes it also an ideal candidate to understand if and how nanoparticle composition affects its localization."
For more information on this research see: In Vivo Fate of Avidin-Nucleic Acid Nanoassemblies as Multifunctional Diagnostic Tools. ACS Nano, 2014;8(1):175-187. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting P. Bigini, Ist Ric Farmacol Mario Negri, IRCCS, Dept. of Cardiovasc Res, I-20156 Milan, Italy. Additional authors for this research include S. Previdi, E. Casarin, D. Silvestri, M.B. Violatto, S. Facchin, L. Sitia, A. Rosato, G. Zuccolotto, N. Realdon, F. Fiordaliso, M. Salmona and M. Morpurgo (see also Proteins).
Keywords for this news article include: Milan, Italy, Europe, Avidin, Ovalbumin, Glycoproteins, Dietary Proteins
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