News Column

Researchers from University of Minnesota Report Findings in Biomedicine and Biomedical Engineering

March 4, 2014

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Biotechnology is the subject of a report. According to news reporting out of Minneapolis, Minnesota, by NewsRx editors, research stated, "Irreversible electroporation (IRE) is a promising technology to treat local malignant cancer using short, high-voltage electric pulses. Unfortunately, in vivo studies show that IRE suffers from an inability to destroy large volumes of cancer tissue without introduction of cytotoxic agents and/or increasing the applied electrical dose to dangerous levels."

Our news journalists obtained a quote from the research from the University of Minnesota, "This research will address this limitation by leveraging membrane-targeting mechanisms that increase lethal membrane permeabilization. Methods that directly modify membrane properties or change the pulse delivery timing are proposed that do not rely on cytotoxic agents. This work shows that significant enhancement (67-75% more cell destruction in vitro and >100% treatment volume increase in vivo) can be achieved using membrane-targeting approaches for IRE cancer destruction. The methods introduced are surfactants (i.e., DMSO) and pulse timing which are low cost, non-toxic, and easy to be incorporated into existing clinical use."

According to the news editors, the research concluded: "Moreover, when needed, these methods can also be combined with electrochemotherapy to further enhance IRE treatment efficacy."

For more information on this research see: Membrane-targeting approaches for enhanced cancer cell destruction with irreversible electroporation. Annals of Biomedical Engineering, 2014;42(1):193-204. Annals of Biomedical Engineering can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer -; Annals of Biomedical Engineering -

Our news journalists report that additional information may be obtained by contacting C. Jiang, Dept. of Mechanical Engineering, University of Minnesota, 111 Church St SE, Minneapolis, MN, 55455, United States. Additional authors for this research include Z. Qin and J. Bischof (see also Biotechnology).

Publisher contact information for the journal Annals of Biomedical Engineering is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Biotechnology, Cancer, Oncology, Minnesota, Treatment, Minneapolis, United States, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cancer Weekly

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