By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting originating in Bethesda, Maryland, by NewsRx journalists, research stated, "Although membrane shape varies greatly throughout the cell, the contribution of membrane curvature to transmembrane protein targeting is unknown because of the numerous sorting mechanisms that take place concurrently in cells. To isolate the effect of membrane shape, we used cell-sized giant unilamellar vesicles (GUVs) containing either the potassium channel KvAP or the water channel AQP0 to form membrane nanotubes with controlled radii."
The news reporters obtained a quote from the research from the National Institute of Neurological Disorders and Stroke, "Whereas the AQP0 concentrations in flat and curved membranes were indistinguishable, KvAP was enriched in the tubes, with greater enrichment in more highly curved membranes. Fluorescence recovery after photobleaching measurements showed that both proteins could freely diffuse through the neck between the tube and GUV, and the effect of each protein on membrane shape and stiffness was characterized using a thermodynamic sorting model."
According to the news reporters, the research concluded: "This study establishes the importance of membrane shape for targeting transmembrane proteins and provides a method for determining the effective shape and flexibility of membrane proteins."
For more information on this research see: Membrane Shape Modulates Transmembrane Protein Distribution. Developmental Cell, 2014;28(2):212-218. Developmental Cell can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier - www.elsevier.com; Developmental Cell - www.elsevier.com/wps/product/cws_home/622228)
Our news correspondents report that additional information may be obtained by contacting S. Aimon, National Institute of Neurological Disorders & Stroke, Mol Physiol & Biophys Sect, Porter Neurosci Res Center, National Institutes of Health, Bethesda, MD 20892, United States. Additional authors for this research include A. Callan-Jones, A. Berthaud, M. Pinot, G.E.S. Toombes and P. Bassereau (see also Life Science Research).
Keywords for this news article include: Bethesda, Maryland, Peptides, Proteins, Amino Acids, United States, Life Science Research, North and Central America
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