By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Apoptosis have been presented. According to news reporting from Columbia, South Carolina, by NewsRx journalists, research stated, "The authors have systematically investigated the anticancer potentiality of silver-based nanoparticles (AgNPs) and the mechanism underlying their biological activity in human colon cancer cells. Starch-capped AgNPs were synthesized, characterized and their biological activity evaluated through multiple biochemical assays."
The news correspondents obtained a quote from the research from the University of South Carolina, "AgNPs decreased the growth and viability of HCT116 colon cancer cells. AgNP exposure increased apoptosis, as demonstrated by an increase in 4',6-diamidino-2-phenylindole-stained apoptotic nuclei, BAX/BCL-XL ratio, cleaved poly(ADP-ribose) polymerase, p53, p21 and caspases 3, 8 and 9, and by a decrease in the levels of AKT and NF-kappa B. The cell population in the G(1) phase decreased, and the S-phase population increased after AgNP treatment. AgNPs caused DNA damage and reduced the interaction between p53 and NF-kB. Interestingly, no significant alteration was noted in the levels of p21, BAX/BCL-XL and NF-kB after AgNP treatment in a p53-knockout HCT116 cell line."
According to the news reporters, the research concluded: "AgNPs are bona fide anticancer agents that act in a p53-dependent manner."
For more information on this research see: Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. Nanomedicine, 2013;8(8):1307-1322. Nanomedicine can be contacted at: Future Medicine Ltd, Unitec House, 3RD Floor, 2 Albert Place, Finchley Central, London, N3 1QB, England. (Elsevier - www.elsevier.com; Nanomedicine - www.elsevier.com/wps/product/cws_home/703416)
Our news journalists report that additional information may be obtained by contacting S.R. Satapathy, University of South Carolina, Dept. of Pharmaceut & Biomed Sci, South Carolina Coll Pharm, Columbia, SC 29208, United States. Additional authors for this research include P. Mohapatra, R. Preet, D. Das, B. Sarkar, T. Choudhuri, M.D. Wyatt and C.N. Kundu (see also Apoptosis).
Keywords for this news article include: Cancer, Columbia, Genetics, Oncology, p53 Gene, Apoptosis, Treatment, Nanoparticle, United States, South Carolina, Nanotechnology, Emerging Technologies, North and Central America
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