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Researchers at California Institute of Technology Release New Data on Myeloid Cells

March 4, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Myeloid Cells. According to news originating from Pasadena, California, by NewsRx correspondents, research stated, "The recent emergence of multimodality imaging, particularly the combination of PET and MRI, has led to excitement over the prospect of improving detection of disease. Iron oxide nanoparticles have become a popular platform for the fabrication of PET/MRI probes owing to their advantages of high MRI detection sensitivity, biocompatibility, and biodegradability."

Our news journalists obtained a quote from the research from the California Institute of Technology, "In this article, we report the synthesis of dextran-coated iron oxide nanoparticles (DIO) labeled with the positron emitter Cu-64 to generate a PET/MRI probe, and modified with maleic anhydride to increase the negative surface charge. The modified nanoparticulate PET/MRI probe (MDIO-Cu-64-DOTA) bears repetitive anionic charges on the surface that facilitate recognition by scavenger receptor type A (SR-A), a ligand receptor found on activated macrophages but not on normal vessel walls. MDIO-Cu-64-DOTA has an average iron oxide core size of 7-8 nm, an average hydrodynamic diameter of 62.7 nm, an r (1) relaxivity of 16.8 mM(-1) s(-1), and an r (2) relaxivity of 83.9 mM(-1) s(-1) (37 A degrees C, 1.4 T). Cell studies confirmed that the probe was nontoxic and was specifically taken up by macrophages via SR-A. In comparison with the nonmodified analog, the accumulation of MDIO in macrophages was substantially improved."

According to the news editors, the research concluded: "These characteristics demonstrate the promise of MDIO-Cu-64-DOTA for identification of vulnerable atherosclerotic plaques via the targeting of macrophages."

For more information on this research see: Multimodality PET/MRI agents targeted to activated macrophages. Journal of Biological Inorganic Chemistry, 2014;19(2):247-258. Journal of Biological Inorganic Chemistry can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Biological Inorganic Chemistry - www.springerlink.com/content/0949-8257/)

The news correspondents report that additional information may be obtained from C.Q. Tu, California Institute of Technology, Beckman Inst, Pasadena, CA 91125, United States. Additional authors for this research include T.S.C. Ng, R.E. Jacobs and A.Y. Louie (see also Myeloid Cells).

Keywords for this news article include: Pasadena, California, Phagocytes, Macrophages, Nanoparticle, United States, Myeloid Cells, Nanotechnology, Emerging Technologies, Connective Tissue Cells, North and Central America

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Source: Life Science Weekly


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