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Research Finds Use of Volpara Solutions Quantitative Breast Imaging Tools Provides Actionable Intelligence for 2D and 3D Mammography Screening of Women with Dense Breasts

February 26, 2014



Vienna, Austria (PRWEB) February 26, 2014

The ability of volumetric breast imaging data to provide actionable intelligence to guide screening of women with dense breasts with 2D and 3D mammography are among the key abstracts accepted for presentation at the European Congress of Radiology (ECR) meeting, March 6-10, 2014. According to Volpara Solutions, seven abstracts highlight the use of quantitative breast imaging software tools to provide Enterprise-wide breast care imaging and informatics, including volumetric density, patient-specific dose, and applied pressure.

The company will showcase the role of its suite of volumetric software tools in a number of large clinical trials, national breast cancer screening programs and hospitals across Europe. (ECR2014 - First level gallery, booth 619).

In the scientific exhibit titled, “Comparing personalized mean glandular dose estimates between x-ray systems over time in mammography” (C-0360), Dr. Ralph Highnam, CEO of Volpara Solutions and a co-author, demonstrates that patient-specific estimates of Mean Glandular Dose (MGD) could be used to help standardize dose monitoring for patients undergoing routine screening on different x-ray systems. The results indicate that the patient-specific estimates of MGD, which incorporate the individual glandularities of the women and use a standard dose algorithm, differ from, but correlate well with the reported doses from GE and Hologic systems. Compared to patient-specific estimates, the mammography systems tended to underestimate MGD.

In the study, “Volumetric breast density estimation on conventional mammography versus digital breast tomosynthesis” (C-0363) VolparaDensity was used to compare the assessment of volumetric breast density of conventional 2D mammograms to assessment of digital breast tomosynthesis (DBT) volumetric density. Results show that there was no significant difference between volumetric breast density, breast volume, and fibroglandular volume estimates from conventional mammograms or the DBT projections. The Volpara generated BI-RADS density scores matched for 19 out of 20 cases, indicating that there was very good agreement between density assessed from the DBT projections and the conventional mammograms. The results suggest that automated volumetric breast density methods are a promising alternative to visually assessed breast density assessments, and produce reliable and objective breast density estimations from both raw conventional mammograms and raw DBT projections.

“While only a few studies have investigated breast density results derived specifically from tomosynthesis, studies have shown significant differences in the density results from 2D and 3D mammography. The current study, using automated volumetric breast density estimations showed very good correlations between the 2D and 3D mammograms, as you might expect given the volumetric nature of the measurement. These results have additional implications for those wanting to monitor longitudinal changes in breast density or for studies looking at breast density as a breast cancer risk factor. Additionally, for sites wanting to implement the C-View module, to replace conventional mammography, automated volumetric methods like VolparaDensity can ensure consistency in breast density measures,” said Dr. Highnam.

Breast cancer screening programs strive to achieve an optimal balance between sensitivity and recall rates. The interpretation of screening mammograms is often challenging and highly variable, but the addition of multiple readers can improve cancer detection rates. While numerous variations in screening protocols have been studied, they have largely sought to apply one protocol across entire populations. In the study, “Effect of independent double and multiple reading of screening mammograms by breast density,” (C-0358) Professor Nico Karssemeijer et al of Nijmegen investigated the effect of increasing the number of independent readers on mammography sensitivity, for dense versus non-dense cases.

“In the United States, breast screening typically comprises annual mammography and single reading with CAD, whereas European guidelines recommend biennial mammography with independent double reading. Double interpretation of mammograms is a proven, effective strategy to improve cancer detection rates,” noted Professor Karssemeijer. “The benefit of additional readers on sensitivity was more pronounced in dense cases, suggesting that tailored screening based on breast density has the potential to improve breast cancer detection rates for this population of women. The allocation of multiple readers to mammograms that may be difficult to interpret offers a relatively simple and effective approach for improving screening performance on women with dense breasts, especially with automated density assessment systems and density-based workflow tools.”

In the study, “Mammographic Density Estimation by Volpara software: Comparison with Radiologists’ visual assessment and relationship with BI-RADS category” (C-1957) Professor L. Han Na of Seoul Korea, compares the automated volumetric breast density measurement with BI-RADS breast density assessed by radiologists’ visual estimates and analyze the clinico-radiologic factors that affect the disagreement. Results demonstrate that the automated volumetric breast density measurement shows good agreement with radiologists’ visual assessment of BI-RADS density category, with differences occurring more often when there were bilateral differences in density.

In addition, on Monday, March 10, 10:30 - 12:00 (Room F2), the Educational Session SS-1702, “Breast density and General Breast MRI,” will include three presentations that feature VolparaDensity:



   •      “Geographical variation in mammographic density distribution in the Netherlands” (B-0832); The preliminary results suggest that geographical variation in mammographic density distribution is present in the Netherlands, which would support structural assessment of breast density within the screening programme;

   •     “Volumetric breast density: can computer assessment really reduce human variability?” (B-0833); Volumetric breast density computer-based can remove inter-reader variability in categorization of dense breasts and following decisions about patient workup.

   •     “Visual and automated volumetric assessment of mammographic density (MD): do measurements depend on the digital mammography unit?” (B-0835); Variances between volumetric density measurements using Volpara™, obtained from GE Senographe and Hologic Selenia mammograms in the same women one year apart, were small and equally distributed in both directions, whereas human visual density scores were statistically significantly more likely to be higher in Senographe mammograms.

Cleared by the FDA, HealthCanada, the TGA and CE-marked, VolparaDensity is used by radiologists to objectively assess density from both digital mammography and tomosynthesis images and help evaluate who might benefit from additional screening. Highly correlated to breast MR assessments, VolparaDensity is a reliable tool which automatically generates an objective, automatic measurement of volumetric breast density and a FDA cleared BI-RADS breast density category. To date, more than 2 million women have had their volumetric breast density analyzed using VolparaDensity.

About Volpara Solutions

Founded to enable radiologists to give women the most accurate information possible regarding their breast health, Volpara Solutions is the wholly owned sales and marketing arm of Matakina Technology Limited of New Zealand. Matakina’s founders and Board of Directors includes John Hood, PhD, former Vice Chancellor of the University of Oxford, UK; Ralph Highnam, PhD, former CEO of Mirada Solutions, one of the University of Oxford’s most successful spin-outs of recent times and co-author of the seminal book Mammographic Image Analysis; and Professor Sir Michael Brady, a serial entrepreneur who recently retired from the University of Oxford where he was Professor of Information Technology for 25 years.

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