The ability of volumetric breast imaging data to provide actionable intelligence to guide screening of women with dense breasts with 2D and 3D mammography are among the key abstracts accepted for presentation at the
The company will showcase the role of its suite of volumetric software tools in a number of large clinical trials, national breast cancer screening programs and hospitals across
In the scientific exhibit titled, “Comparing personalized mean glandular dose estimates between x-ray systems over time in mammography” (C-0360), Dr.
In the study, “Volumetric breast density estimation on conventional mammography versus digital breast tomosynthesis” (C-0363) VolparaDensity was used to compare the assessment of volumetric breast density of conventional 2D mammograms to assessment of digital breast tomosynthesis (DBT) volumetric density. Results show that there was no significant difference between volumetric breast density, breast volume, and fibroglandular volume estimates from conventional mammograms or the DBT projections. The Volpara generated BI-RADS density scores matched for 19 out of 20 cases, indicating that there was very good agreement between density assessed from the DBT projections and the conventional mammograms. The results suggest that automated volumetric breast density methods are a promising alternative to visually assessed breast density assessments, and produce reliable and objective breast density estimations from both raw conventional mammograms and raw DBT projections.
“While only a few studies have investigated breast density results derived specifically from tomosynthesis, studies have shown significant differences in the density results from 2D and 3D mammography. The current study, using automated volumetric breast density estimations showed very good correlations between the 2D and 3D mammograms, as you might expect given the volumetric nature of the measurement. These results have additional implications for those wanting to monitor longitudinal changes in breast density or for studies looking at breast density as a breast cancer risk factor. Additionally, for sites wanting to implement the C-View module, to replace conventional mammography, automated volumetric methods like VolparaDensity can ensure consistency in breast density measures,” said Dr. Highnam.
Breast cancer screening programs strive to achieve an optimal balance between sensitivity and recall rates. The interpretation of screening mammograms is often challenging and highly variable, but the addition of multiple readers can improve cancer detection rates. While numerous variations in screening protocols have been studied, they have largely sought to apply one protocol across entire populations. In the study, “Effect of independent double and multiple reading of screening mammograms by breast density,” (C-0358) Professor
“In the United States, breast screening typically comprises annual mammography and single reading with CAD, whereas European guidelines recommend biennial mammography with independent double reading. Double interpretation of mammograms is a proven, effective strategy to improve cancer detection rates,” noted Professor Karssemeijer. “The benefit of additional readers on sensitivity was more pronounced in dense cases, suggesting that tailored screening based on breast density has the potential to improve breast cancer detection rates for this population of women. The allocation of multiple readers to mammograms that may be difficult to interpret offers a relatively simple and effective approach for improving screening performance on women with dense breasts, especially with automated density assessment systems and density-based workflow tools.”
In the study, “Mammographic Density Estimation by Volpara software: Comparison with Radiologists’ visual assessment and relationship with BI-RADS category” (C-1957) Professor
In addition, on
• “Geographical variation in mammographic density distribution in the Netherlands” (B-0832); The preliminary results suggest that geographical variation in mammographic density distribution is present in
• “Volumetric breast density: can computer assessment really reduce human variability?” (B-0833); Volumetric breast density computer-based can remove inter-reader variability in categorization of dense breasts and following decisions about patient workup.
• “Visual and automated volumetric assessment of mammographic density (MD): do measurements depend on the digital mammography unit?” (B-0835); Variances between volumetric density measurements using Volpara™, obtained from GE Senographe and Hologic Selenia mammograms in the same women one year apart, were small and equally distributed in both directions, whereas human visual density scores were statistically significantly more likely to be higher in Senographe mammograms.
Cleared by the
About Volpara Solutions
Founded to enable radiologists to give women the most accurate information possible regarding their breast health, Volpara Solutions is the wholly owned sales and marketing arm of
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Read the full story at http://www.prweb.com/releases/2014/02/prweb11618138.htm
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