News Column

Reports Summarize Molecular Biology Findings from Yonsei University

March 4, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting originating in Gangwon Do, South Korea, by NewsRx journalists, research stated, "Ultrasound Contrast Agents (UCAs) were developed to maximize reflection contrast so that organs can be seen clearly in ultrasound imaging. UCAs increase the signal to noise ratio (SNR) by linear and non-linear mechanisms and thus help more accurately visualize the internal organs and blood vessels."

The news reporters obtained a quote from the research from Yonsei University, "However, the UCAs on the market are not only expensive, but are also not optimized for use in various therapeutic research applications such as ultrasound-aided drug delivery. The UCAs fabricated in this study utilize conventional lipid and albumin for shell formation and perfluorobutane as the internal gas. The shape and density of the UCA bubbles were verified by optical microscopy and Cryo SEM, and compared to those of the commercially available UCAs, Definity® and Sonovue®. The size distribution and characteristics of the reflected signal were also analyzed using a particle size analyzer and ultrasound imaging equipment. Our experiments indicate that UCAs composed of spherical microbubbles, the majority of which were smaller than 1 um, were successfully synthesized. Microbubbles 10 um or larger were also identified when different shell characteristics and filters were used."

According to the news reporters, the research concluded: "These laboratory UCAs can be used for research in both diagnoses and therapies."

For more information on this research see: Synthesis of Laboratory Ultrasound Contrast Agents. Molecules, 2013;18(10):13078-13095. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer -; Molecules -

Our news correspondents report that additional information may be obtained by contacting J. Park, Yonsei University, Dept. of Chem & Med Chem, Wonju 220710, Gangwon Do, South Korea. Additional authors for this research include D. Park, U. Shin, S. Moon, C. Kim, H.S. Kim, H. Park, K. Choi, B.K. Jung, J. Oh and J. Seo (see also Life Science Research).

Keywords for this news article include: Asia, Gangwon Do, South Korea, Life Science Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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