By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Nanotechnology have been presented. According to news reporting originating in Cambridge, Massachusetts, by NewsRx journalists, research stated, "Melanoma skin cancer is one of the most dangerous skin cancers and the main cause of skin-cancer-related mortality. Hyaluronic acid (HA) has been used as an effective transdermal delivery carrier of chemical drugs and biopharmaceuticals."
The news reporters obtained a quote from the research from Massachusetts General Hospital, "In this work, a nanographene oxide-HA conjugate (NGO-HA) was synthesized for photothermal ablation therapy of melanoma skin cancer using a near-infrared (NIR) laser. Confocal microscopy and ex vivo bioimaging clearly visualized the remarkable transdermal delivery of NGO-HA to tumor tissues in the skin of mice, which might be ascribed to highly expressed HA receptors and relatively leaky structures around tumor tissues, enabling the enhanced permeation and retention of nanoparticles. The NIR irradiation resulted in complete ablation of tumor tissues with no recurrence of tumorigenesis. The antitumor effect was confirmed by ELISA for caspase-3 activity and histological and immunohistochemical analyses with TUNEL assay for tumor apoptosis."
According to the news reporters, the research concluded: "Taken together, we could confirm the feasibility of transdermal NGO-HA for photothermal ablation therapy of melanoma skin cancers."
For more information on this research see: Nanographene Oxide-Hyaluronic Acid Conjugate for Photothermal Ablation Therapy of Skin Cancer. ACS Nano, 2014;8(1):260-268. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting H.S. Jung, Massachusetts General Hospital, Cambridge, MA 02139, United States. Additional authors for this research include W.H. Kong, D.K. Sung, M.Y. Lee, S.E. Beack, D.H. Keum, K.S. Kim, S.H. Yun and S.K. Hahn (see also Nanotechnology).
Keywords for this news article include: Cancer, Therapy, Oncology, Cambridge, Massachusetts, United States, Nanotechnology, North and Central America
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