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Recent Studies from MRC Laboratory of Molecular Biology Add New Data to Molecular Recognition

March 4, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Molecular Recognition is the subject of a report. According to news reporting out of Cambridge, United Kingdom, by NewsRx editors, research stated, "The yeast poly(A) RNA binding protein, Nab2, facilitates poly(A) tail length regulation together with targeting transcripts to nuclear pores and their export to the cytoplasm. Nab2 binds polyadenosine RNA primarily through a tandem repeat of CCCH Zn fingers."

Our news journalists obtained a quote from the research from the MRC Laboratory of Molecular Biology, "We report here the 2.15 A resolution crystal structure of Zn fingers 3-5 of Chaetomium thermophilum Nab2 bound to polyadenosine RNA and establish the structural basis for the molecular recognition of adenosine ribonucleotides. Zn fingers 3 and 5 each bind two adenines, whereas finger 4 binds only one. In each case, the purine ring binds in a surface groove, where it stacks against an aromatic side chain, with specificity being provided by a novel pattern of H-bonds, most commonly between purine N6 and a Zn-coordinated cysteine supplemented by H-bonds between purine N7 and backbone amides. Residues critical for adenine binding are conserved between species and provide a code that allows prediction of finger-binding stoichiometry based on their sequence."

According to the news editors, the research concluded: "Moreover, these results indicate that, in addition to poly(A) tails, Nab2 can also recognize sequence motifs elsewhere in transcripts in which adenosines are placed at key positions, consistent with its function in mRNP organization and compaction as well as poly(A) tail length regulation."

For more information on this research see: Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers. Nucleic Acids Symposium Series, 2014;42(1):672-80. (Oxford University Press -; Nucleic Acids Symposium Series -

Our news journalists report that additional information may be obtained by contacting S.I. Kuhlmann, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. Additional authors for this research include E. Valkov and M. Stewart (see also Molecular Recognition).

Keywords for this news article include: Europe, Cambridge, United Kingdom, Nanotechnology, Emerging Technologies, Molecular Recognition.

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Source: Life Science Weekly

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