By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Nanoparticles. According to news reporting out of West Long Branch, New Jersey, by NewsRx editors, research stated, "In this study, a novel orodispersible film (ODF) containing drug nanoparticles was developed with the goal of transforming drug nanosuspensions into a solid dosage form and enhancing oral bioavailability of drugs with poor water solubility. Nanosuspensions were prepared by high pressure homogenization and then transformed into ODF containing drug nanoparticles by mixing with hydroxypropyl methylcellulose solution containing microcrystalline cellulose, low substituted hydroxypropylcellulose and PEG-400 followed by film casting and drying."
Our news journalists obtained a quote from the research from Monmouth University, "Herpetrione, a novel and potent antiviral agent with poor water solubility that extracted from Herpetospermum caudigerum, was chosen as a model drug and studied systematically. The uniformity of dosage units of the preparation was acceptable according to the criteria of Japanese Pharmacopoeia 15. The ODF was disintegrated in water within 30 s with reconstituted nanosuspensions particle size of 280 +/- 11 nm, which was similar to that of drug nanosuspensions, indicating a good redispersibility of the fast dissolving film. Result of X-ray diffraction showed that HPE in the ODF was in the amorphous state. In the in vitro dissolution test, the ODF containing HPE nanoparticles showed an increased dissolution velocity markedly. In the pharmacokinetics study in rats, compared to HPE coarse suspensions, the ODF containing HPE nanoparticles exhibited significant increase in AUC(0-24h), C-max and decrease in T-max, MRT."
According to the news editors, the research concluded: "The result revealed that the ODF containing drug nanoparticles may provide a potential opportunity in transforming drug nanosuspensions into a solid dosage form as well as enhancing the dissolution rate and oral bioavailability of poorly water-soluble drugs."
For more information on this research see: Development and characterization of an orodispersible film containing drug nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics, 2013;85(3):1348-1356. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.elsevier.com/wps/product/cws_home/600120)
Our news journalists report that additional information may be obtained by contacting B.D. Shen, Monmouth Univ, Sch Sci, West Long Branch, NJ, United States. Additional authors for this research include C.Y. Shen, X.D. Yuan, J.X. Bai, Q.Y. Lv, H. Xu, L. Dai, C. Yu, J. Han and H.L. Yuan (see also Nanoparticles).
Keywords for this news article include: New Jersey, United States, Nanotechnology, West Long Branch, Emerging Technologies, North and Central America
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