By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on DNA Research is now available. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Herein, we report a convenient approach to developing quantum dots (QDs)-based nanosensors for DNA and micro-RNA (miRNA) detection. The DNA-QDs conjugate was prepared by a ligand-exchange method."
The news reporters obtained a quote from the research from the Shanghai Institute of Applied Physics, "Thiollabeled ssDNA is directly attached to the QD surface, leading to highly water-dispersible nanoconjugates. The DNA-QDs conjugate has the advantages of the excellent optical properties of QDs and well-Controlled recognition properties of DNA and can be used as a nanoprobe to construct a nanosensor for nucleic acid detection. With the addition of a target nucleic acid sequence, the fluorescence intensity of QDs was quenched by an organic quencher (BHQ(2)) via Forster resonance energy transfer. This nanosensor can detect as low as 1 fM DNA and 10 fM miRNA. Moreover, the QDs-based nanosensor exhibited excellent selectivity. It not only can effectively distinguish single-base-mismatched and random nucleic sequences but also can recognize pre-miRNA and mature miRNA."
According to the news reporters, the research concluded: "Therefore, the nanosensor has high application potential for disease diagnosis and biological analysis."
For more information on this research see: DNA-Conjugated Quantum Dot Nanoprobe for High-Sensitivity Fluorescent Detection of DNA and micro-RNA. ACS Applied Materials & Interfaces, 2014;6(2):1152-1157. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news correspondents report that additional information may be obtained by contacting S. Su, Academy Sinica, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, People's Republic of China. Additional authors for this research include J.W. Fan, B. Xue, L.H. Yuwen, X.F. Liu, D. Pan, C.H. Fan and L.H. Wang (see also DNA Research).
Keywords for this news article include: Asia, Shanghai, DNA Research, Quantum Dots, Nanotechnology, Emerging Technologies, People's Republic of China
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