By a News Reporter-Staff News Editor at Clinical Trials Week -- Data detailed on Clinical Research have been presented. According to news reporting originating in Chernogolovka, Russia, by NewsRx journalists, research stated, "We report a comparative investigation of the antibacterial activity of two water-soluble fullerene derivatives bearing protonated amine (AF) and deprotonated carboxylic (CF) groups appended to the fullerene cage via organic linkers. The negatively charged fullerene derivative CF showed no tendency to bind to the bacterial cells and, consequently, no significant antibacterial activity."
The news reporters obtained a quote from the research from the Institute of Problems of Chemical Physics, "In contrast, the compound AF loaded with cationic groups showed strong and partially irreversible binding to the negatively charged Escherichia coli K12 TG1 cells and to human erythrocytes, also possessing negative zeta potential. Adsorption of AF on the bacterial surface was visualized by atomic force microscopy revealing the formation of specific clusters (AF aggregates) surrounding the bacterial cell. Incubation of E. coli K12 TG1 with AF led to a dose-dependent bactericidal effect with LD50 = 79.1 mu M. The presence of human erythrocytes in the test medium decreased the AF antibacterial activity."
According to the news reporters, the research concluded: "Thus we reveal that the water-soluble cationic fullerene derivative AF possesses promising antibacterial activity, which might be utilized in the development of novel types of chemical disinfectants."
For more information on this research see: The Activity of Fullerene Derivatives Bearing Amine and Carboxylic Solubilizing Groups against Escherichia coli: A Comparative Study. Journal of Nanomaterials, 2014;():1-9. Journal of Nanomaterials can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nanomaterials - www.hindawi.com/journals/jnm/)
Our news correspondents report that additional information may be obtained by contacting D.G. Deryabin, Inst Problems Chem Phys RAS, Chernogolovka 142432, Moscow Region, Russia. Additional authors for this research include O.K. Davydova, Z.Z.H. Yankina, A.S. Vasilchenko, S.A.Miroshnikov, A.B. Kornev, A.V. Ivanchikhina and P.A. Troshin (see also Clinical Research).
Keywords for this news article include: Russia, Carbon, Eurasia, Fullerenes, Immunology, Blood Cells, Erythrocytes, Chernogolovka, Nanotechnology, Escherichia coli, Clinical Research, Enterobacteriaceae, Emerging Technologies, Gram-Negative Bacteria, Clinical Trials and Studies
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC