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Metabolon Signs Pact with the Carlos Slim Institute, Patia and Clinica Ruiz for Quantose Prediabetes Test in Mexico

February 27, 2014

Metabolon, a metabolomics company, announced the signing of several exclusive multi-year, royalty-based Research Collaboration and Licensing agreements with Patia Biopharma, a Mexican biotech company working to make personalized preventive medicine a reality in Mexico and Latin America.

According to a release, the Research Collaboration provides Metabolon's Quantose IR technology for use in several Diabetes Prevention Studies in Mexico. The License agreement provides exclusive access in Mexico to Metabolon's prediabetes test technology for assessing insulin resistance in the general population of Mexico through Patia and Clinica Ruiz's network of laboratories.

Under the terms of the agreements, the Company noted that Patia and its affiliates will use Metabolon's Quantose IR technology in unprecedented large-scale studies in Mexico to test for prediabetes in up to 3 million overweight or obese adults and secondary school students who are obese and/or have a family history of diabetes. The goal of these studies is to detect prediabetes early and prescribe treatment to prevent progression to type 2 diabetes. Testing will be carried out over four years, beginning with pilot studies in 2014.

The Metabolon prediabetes test uses a multi-analyte assay that requires only a single fasting blood sample. All testing will be performed at the laboratories of Clinica Ruiz, an ANAB-accredited laboratory, utilizing its mass spectrometry analysis technology and a laboratory developed test (LDT) derived from Metabolon's Quantose IR technology.

According to a recent article in The Economist, diabetes is one of the top two causes of death in Mexico, responsible for 70,000 deaths annually. "We intend to reverse the growing incidence of diabetes and impact public health policy in Mexico, and perhaps throughout Latin America," commented Laureano Simon, Ph.D., Chief Executive Officer of Patia. "The Quantose IR technology provides us with an important new tool to identify patients with prediabetes so that appropriate treatment can be prescribed to prevent progression to type 2 diabetes."

"The licensing of Quantose IR technology to Patia is a key milestone in our expansion in obesity-related diagnostics outside of the U.S.," stated John Ryals, Ph.D., President and Chief Executive Officer of Metabolon. "We are delighted to be partnering in this visionary program with Patia in Mexico, with the goal of impacting healthcare policy in Mexico and throughout Latin America. These two trials are the largest of this type ever conducted, and we look forward to having the results made public and published in peer- reviewed medical journals. What's more, commercialization of our test for prediabetes in the general populations in Mexico through Patia and Clinica Ruiz could lead to positive outcomes as it relates to prevention of the progression to type 2 diabetes through appropriate therapies."

Quantose IR is a novel blood test for prediabetes that reflects insulin resistance. The test is based on three recently identified non-glycemic biomarkers and insulin, and is used as an aid in the detection of prediabetes. By reflecting insulin resistance, Quantose IR provides clinicians with a useful tool that may identify prediabetes earlier than traditional glycemic measures.

Patia Biopharma is a company focused on promoting personalized preventive medicine.

More Information:

www.patia.com.mx

www.metabolon.com

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