By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology is the subject of a report. According to news reporting out of St. Leonards, Australia, by NewsRx editors, research stated, "Tissue protein expression profiling has the potential to detect new biomarkers to improve breast cancer (BC) diagnosis, staging, and prognostication. This study aimed to identify tissue proteins that differentiate breast cancer tissue from healthy breast tissue using protein chip mass spectrometry and to examine associations with conventional pathological features."
Our news journalists obtained a quote from the research from the University of Sydney, "To develop a training model, 82 BC and 82 adjacent unaffected tissue (AT) samples were analysed on cation-exchange protein chips by time-of-flight mass spectrometry. For validation, 89 independent BC and AT sample pairs were analysed. From the protein peaks that were differentially expressed between BC and AT by univariate analysis, binary logistic regression yielded two peaks that together classified BC and AT with a ROC area under the curve of 0.92. Two proteins, ubiquitin and S100P (in a novel truncated form), were identified by liquid chromatography/tandem mass spectrometry and validated by immunoblotting and reactive-surface protein chip immunocapture. The combined marker panel was positively associated with high histologic grade, larger tumor size, lymphovascular invasion, ER and PR positivity, and HER2 overexpression, suggesting that it may be associated with a HER2-enriched molecular subtype of breast cancer."
According to the news editors, the research concluded: "This independently validated protein panel may be valuable in the classification and prognostication of breast cancer patients."
For more information on this research see: Tissue biomarkers of breast cancer and their association with conventional pathologic features. British Journal of Cancer, 2013;108(2):351-60. (Nature Publishing Group - www.nature.com/; British Journal of Cancer - www.nature.com/bjc/)
Our news journalists report that additional information may be obtained by contacting L. Chung, Hormones and Cancer Division, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia. Additional authors for this research include S. Shibli, K. Moore, E.E. Elder, F.M. Boyle, D.J. Marsh and R.C Baxter (see also Oncology).
Keywords for this news article include: Oncology, St. Leonards, Breast Cancer, Protein Chips, Nanotechnology, Women's Health, Emerging Technologies, Australia and New Zealand.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC