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Findings in the Area of Nanoparticles Reported from Nankai University

March 4, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting originating in Tianjin, People's Republic of China, by NewsRx journalists, research stated, "Core-shell molecular imprinting of nanomaterials overcomes difficulties with template transfer and achieves higher binding capacities for macromolecular imprinting, which are more important to the imprinting of natural low-abundance proteins from cell extracts. In the present study, a novel strategy of preparing core-shell nanostructured molecularly imprinted polymers (MIPs) was developed that combined the core-shell approach with assistant recognition polymer chains (ARPCs)."

The news reporters obtained a quote from the research from Nankai University, "Vinyl-modified silica nanoparticles were used as support and ARPCs were used as additional functional monomers. Immunoglobulin heavy chain binding protein (BiP) from the endoplasmic reticulum (ER) was chosen as the model protein. The cloned template protein BiP was selectively assembled with ARPCs from their library, which contained numerous limited-length polymer chains with randomly distributed recognition and immobilization sites. The resulting complex was copolymerized onto the surface of vinyl-modified silica nanoparticles under low concentrations of the monomers. After template removal, core-shell-structured nanoparticles with a thin imprinted polymer layer were produced. The particles demonstrated considerably high adsorption capacity, fast adsorption kinetics and selective binding affinities toward the template BiP. Furthermore, the synthesized MIP nanoparticles successfully isolated cloned protein BiP from protein mixtures and highly enriched BiP from an ER extract containing thousands of kinds of proteins. The enrichment reached 115-fold and the binding capacity was 5.4 ?g g(-1), which were higher than those achieved by using traditional MIP microspheres."

According to the news reporters, the research concluded: "The advantageous properties of MIP nanoparticles hold promise for further practical applications in biology, such as protein analysis and purification."

For more information on this research see: Core-shell molecularly imprinted polymer nanoparticles with assistant recognition polymer chains for effective recognition and enrichment of natural low-abundance protein. Acta Biomaterialia, 2014;10(2):769-75. (Elsevier -; Acta Biomaterialia -

Our news correspondents report that additional information may be obtained by contacting D. Liu, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, People's Taiwan. Additional authors for this research include Q. Yang, S. Jin, Y. Song, J. Gao, Y. Wang and H. Mi (see also Nanoparticles).

Keywords for this news article include: Asia, Tianjin, Nanotechnology, Emerging Technologies, People's Republic of China.

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Source: Life Science Weekly

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