By a News Reporter-Staff News Editor at Science Letter -- Data detailed on Science have been presented. According to news reporting out of Copenhagen, Denmark, by NewsRx editors, research stated, "In this work, a single-well electromembrane extraction (EME) device was developed based on a thin (100 mu m) and flat porous membrane of polypropylene supporting a liquid membrane. The new EME device was operated with a relatively large acceptor solution volume to promote a high recovery."
Our news journalists obtained a quote from the research from the University of Copenhagen, "Using this EME device, exhaustive extraction of the basic drugs quetiapine, citalopram, amitriptyline, methadone and sertraline was investigated from both acidified water samples and human plasma. The volume of acceptor solution, extraction time, and extraction voltage were found to be important factors for obtaining exhaustive extraction. 2-Nitrophenyl octyl ether was selected as the optimal organic solvent for the supported liquid membrane. From spiked acidified water samples (600 mu l), EME was carried out with 600 mu l of 20 mM HCOOH as acceptor solution for 15 min and with an extraction voltage of 250 V. Under these conditions, extraction recoveries were in the range 89-112%. From human plasma samples (600 mu l), EME was carried out with 600 mu l of 20 mM HCOOH as acceptor solution for 30 min and with an extraction voltage of 300V. Under these conditions, extraction recoveries were in the range of 83-105%. When combined with LC-MS, the new EME device provided linearity in the range 10-1000 ng/ml for all analytes (R-2 > 0.990). The repeatability at low (10 ng/ml), medium (100 ng/ml), and high (1000 ng/ml) concentration level for all five analytes were less than 10% (RSD)."
According to the news editors, the research concluded: "The limits of quantification (S/N = 10) were found to be in the range 0.7-6.4 ng/ml."
For more information on this research see: Development of a flat membrane based device for electromembrane extraction: A new approach for exhaustive extraction of basic drugs from human plasma. Journal of Chromatography A, 2014;1326():7-12. Journal of Chromatography A can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Chromatography A - www.elsevier.com/wps/product/cws_home/502688)
Our news journalists report that additional information may be obtained by contacting C.X. Huang, University of Copenhagen, Dept. of Pharm, Fac Hlth & Med Sci, DK-2100 Copenhagen, Denmark. Additional authors for this research include L.E.E. Eibak, A. Gjelstad, X.T. Shen, R. Trones, H. Jensen and S. Pedersen-Bjergaard (see also Science).
Keywords for this news article include: Europe, Denmark, Science, Copenhagen
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