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Reports from B. Wang and Co-Researchers Add New Data to Findings in Molecular Research

February 28, 2014

By a News Reporter-Staff News Editor at Science Letter -- Current study results on Molecular Research have been published. According to news reporting from Guangdong, People's Republic of China, by NewsRx journalists, research stated, "Magnesium and its alloysa new class of degradable metallic biomaterialsare being increasingly investigated as a promising alternative for medical implant and device applications due to their advantageous mechanical and biological properties. However, the high corrosion rate in physiological environments prevents the clinical application of Mg-based materials."

The news correspondents obtained a quote from the research, "Therefore, the objective of this study was to develop a hydroxyapatite (HA) coating on ZK60 magnesium alloy substrates to mediate the rapid degradation of Mg while improving its cytocompatibility for orthopedic applications. A simple chemical conversion process was applied to prepare HA coating on ZK60 magnesium alloy. Surface morphology, elemental compositions, and crystal structures were characterized using scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction, respectively. The corrosion properties of samples were investigated by immersion test and electrochemical test. Murine fibroblast L-929 cells were harvested and cultured with coated and non-coated ZK60 samples to determine cytocompatibility. The degradation results suggested that the HA coatings decreased the degradation of ZK60 alloy. No significant deterioration in compression strength was observed for all the uncoated and coated samples after 2 and 4 weeks' immersion in simulated body fluid (SBF)."

According to the news reporters, the research concluded: "Cytotoxicity test indicated that the coatings, especially HA coating, improved cytocompatibility of ZK60 alloy for L929 cells."

For more information on this research see: In Vitro Corrosion and Cytocompatibility of ZK60 Magnesium Alloy Coated with Hydroxyapatite by a Simple Chemical Conversion Process for Orthopedic Applications. International Journal of Molecular Sciences, 2013;14(12):23614-23628. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Molecular Research).

Our news journalists report that additional information may be obtained by contacting B. Wang, Southern Med Univ, Key Lab Construct & Detect Guangdong Prov, Guangzhou 510515, Guangdong, People's Republic of China. Additional authors for this research include P. Huang, C.W. Ou, K.K. Li, B. Yan and W. Lu.

Keywords for this news article include: Asia, Guangdong, Magnesium, Light Metals, Molecular Research, People's Republic of China

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Source: Science Letter

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