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New Findings from Chulalongkorn University in the Area of Nanoparticles Described

February 28, 2014

By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Nanoparticles. According to news reporting originating in Bangkok, Thailand, by NewsRx journalists, research stated, "Gold nanoparticles stabilized by thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAM-AuNPs) were prepared by surface grafting of thiol-terminated PNIPAM onto citrate-stabilized AuNPs. The color change of the PNIPAM-AuNPs solution from red to blue-purple without precipitation when the solution was heated to 40 degrees C, above the lower critical solution temperature (LCST) of PNIPAM, indicated the thermoresponsive property of the synthesized AuNPs."

The news reporters obtained a quote from the research from Chulalongkorn University, "PNIPAM-AuNPs were used to detect proteins by chemical nose approach based on fluorescence quenching of fluorophore by AuNPs. An array-based sensing platform for.detection of six proteins, namely bovine serum albumin, lysozyme, fibrinogen, concanavalin A, hemoglobin, holo-transferrin human can be successfully developed from the PNIPAM-AuNPs having different molecular weights (4 and 8 kDa) and conformation (varied heat treatment from 25 to 40 degrees C) in combination with a tricationic branched phenylene-ethynylene fluorophore."

According to the news reporters, the research concluded: "From principal component analysis (PCA) followed by linear discriminant analysis (LDA), 100% accuracy of protein classification using a leave-one-out (LOO) approach can be achieved by using only two types of PNIPAM-AuNPs."

For more information on this research see: Poly(N-isopropylacrylamide)-Stabilized Gold Nanoparticles in Combination with Tricationic Branched Phenylene-Ethynylene Fluorophore for Protein Identification. Langmuir, 2013;29(39):12317-12327. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Langmuir -

Our news correspondents report that additional information may be obtained by contacting K. Kusolkamabot, Chulalongkorn University, Fac Sci, Dept. of Chem, Organ Synth Res Unit, Bangkok 10330, Thailand. Additional authors for this research include P. Sae-ung, N. Niamnont, K. Wongravee, M. Sukwattanasinitt and V.P. Hoven (see also Nanoparticles).

Keywords for this news article include: Asia, Bangkok, Thailand, Nanotechnology, Gold Nanoparticles, Emerging Technologies

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Source: Science Letter

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