By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Enzymes and Coenzymes. According to news originating from Edmonton, Canada, by NewsRx correspondents, research stated, "Ribbonfish (Trichiurus haumela) backbone is normally discarded as an industrial waste from fish processing. A method of developing angiotensin I-converting enzyme inhibitory (ACEI) peptides from ribbonfish backbone was previously optimized."
Our news journalists obtained a quote from the research from the University of Alberta, "The purposes of the study were to characterize the active peptides in the hydrolysate and to evaluate its in vivo activity. Ribbonfish backbone protein hydrolysate prepared by acid protease was fractionated into 4 fractions (I, MW < 1 kDa; II, MW= 1 to 5 kDa; III, MW= 5 to 10 kDa; and IV, MW > 10 kDa) through ultrafiltration membranes. Fraction I, showing the highest ACEI activity, was further purified using consecutive chromatographic techniques including gel filtration and reversed phase high-performance liquid chromatography. The purified ACE inhibitory peptide was determined to have a molecular weight of 317.25 Da, with a sequence of Leu-Trp and an IC50 value of 5.6M. Systolic blood pressure of spontaneously hypertensive rats was significantly decreased from 181 2.0 to 161.3 +/- 2.3mm Hg after 4h of oral administration of Leu-Trp at a dose of 10mg/kg of body weight."
According to the news editors, the research concluded: "These results indicated that ribbonfish backbone protein could be used for development of antihypertensive agent."
For more information on this research see: Purification, Identification, and In Vivo Activity of Angiotensin I-Converting Enzyme Inhibitory Peptide, from Ribbonfish (Trichiurus haumela) Backbone. Journal of Food Science, 2014;79(1):C1-C7. Journal of Food Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Food Science - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1750-3841)
The news correspondents report that additional information may be obtained from P. Zou, University of Alberta, Dept. of Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada. Additional authors for this research include J.L. Wang, G.Q. He and J.P. Wu (see also Enzymes and Coenzymes).
Keywords for this news article include: Canada, Alberta, Edmonton, Autacoids, Angiotensin I, Neuropeptides, Oligopeptides, Peptide Hormones, Enzymes and Coenzymes, North and Central America
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