By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Nanoparticles is the subject of a report. According to news originating from Macao, People's Republic of China, by NewsRx correspondents, research stated, "Triptolide (TP) often causes adverse reactions in the gastrointestinal tract when it is administered orally. This study aimed to prepare and optimize triptolide-loaded solid lipid nanoparticles (TP-SLN) with reduced gastric irritation."
Our news journalists obtained a quote from the research from the University of Macau, "The microemulsion technique was used to formulate TP-SLN employing a five-level central composite design (CCD) that was developed for exploring the optimum levels of three independent variables on particle size, encapsulation efficiency (EE) and drug loading (DL). Quadratic polynomial models were generated to predict and evaluate the three independent variables with respect to the three responses. The optimized TP-SLN was predicted to comprise fraction of lipid of 49.73%, surfactant to co-surfactant ratio of 3.25, and lipid to drug ratio of 55.27, which showed particle size of 179.8 +/- 5.7 nm, EE of 56.5 +/- 0.18% and DL of 1.02 +/- 0.003% that were in good agreement with predicted values. In addition, the optimized nanoparticles manifested a sustained-release pattern in vitro and were stable during 3 h of incubation in simulated gastric fluids without significant size change and the majority (91%) of the drug was protected."
According to the news editors, the research concluded: "Furthermore, the nanoparticles did not show obvious gastric irritation caused by oral administration of TP in rats."
For more information on this research see: Preparation and Optimization of Triptolide-Loaded Solid Lipid Nanoparticles for Oral Delivery with Reduced Gastric Irritation. Molecules, 2013;18(11):13340-13356. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)
The news correspondents report that additional information may be obtained from C. Zhang, Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macao, People's Republic of China. Additional authors for this research include C.H. Gu, F. Peng, W. Liu, J.L. Wan, H.B. Xu, C.W. Lam and X.L. Yang (see also Nanoparticles).
Keywords for this news article include: Asia, Macao, Nanotechnology, Emerging Technologies, People's Republic of China
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