News Column

Studies from Taipei City Hospital Update Current Data on Molecular Biology

February 25, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Life Science Research are presented in a new report. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "Di-(2-ethylhexyl) phthalate (DEHP) is used to increase the flexibility of plastics for industrial products. However, the illegal use of the plasticizer DEHP in food and drinks has been reported in Taiwan in 2011."

Our news journalists obtained a quote from the research from Taipei City Hospital, "In order to assess the exact extent of the absorption of DEHP via the oral route, the aim of this study is to develop a reliable and validated ultra performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method to evaluate the oral bioavailability of DEHP in rats. The optimal chromatographic separation of DEHP and butyl benzyl phthalate (BBP; used as internal standard) were achieved on a C-18 column. The mobile phase was consisted of 5 mM ammonium acetate-methanol (11:89, v/v) with a flow rate of 0.25 mL/min. The monitoring ion transitions were m/z 391.4 ? 149.0 for DEHP and m/z 313.3 ? 149.0 for BBP. The mean matrix effects of DEHP at low, medium and high concentrations were 94.5 +/- 5.7% and 100.1 +/- 2.3% in plasma and feces homogenate samples, respectively."

According to the news editors, the research concluded: "The validated UPLC-MS/MS method is suitable for analyzing the rat plasma sample of DEHP and the oral bioavailability of DEHP was about 7% in rats."

For more information on this research see: Determination and Pharmacokinetics of Di-(2-ethylhexyl) Phthalate in Rats by Ultra Performance Liquid Chromatography with Tandem Mass Spectrometry. Molecules, 2013;18(9):11452-11466. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)

The news correspondents report that additional information may be obtained from W.L. Chang-Liao, Taipei City Hosp, Dept. of Educ & Res, Taipei 103, Taiwan. Additional authors for this research include M.L. Hou, L.W. Chang, C.J. Lee, Y.M. Tsai, L.C. Lin and T.H. Tsai (see also Life Science Research).

Keywords for this news article include: Asia, Taipei, Taiwan, Life Science Research

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Source: Life Science Weekly


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