Our news editors obtained a quote from the research, "Here, we study the adsorption of insulin onto gold NPs (mean hydrodynamic particle diameter 80 +/- A 18 nm), focusing on the structural consequences of the adsorption process for the protein. We use surface enhanced Raman scattering (SERS) spectroscopy to study changes in the protein's secondary structure as well as the impact on integrity and conformations of disulfide bonds immediately on the NP surface. A detailed comparison to SERS spectra of cysteine and cystine provides first mechanistic insights into the causes for these conformational changes."
According to the news editors, the research concluded: "Potential biological and toxicological implications of these findings are also discussed."
For more information on this research see: Mechanistic aspects of protein corona formation: insulin adsorption onto gold nanoparticle surfaces.
The news editors report that additional information may be obtained by contacting S. Grass, Fraunhofer ICT IMM, D-55129 Mainz,
Keywords for this news article include: Mainz,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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