By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Biomembranes have been presented. According to news reporting originating from East Lansing, Michigan, by NewsRx correspondents, research stated, "Engineered nanomaterials (ENM) have desirable properties that make them well suited for many commercial applications. However, a limited understanding of how ENM's properties influence their molecular interactions with biomembranes hampers efforts to design ENM that are both safe and effective."
Our news editors obtained a quote from the research from Michigan State University, "This paper describes the use of a tethered bilayer lipid membrane (tBLM) to characterize biomembrane disruption by functionalized silica-core nanoparticles. Electrochemical impedance spectroscopy was used to measure the time trajectory of tBLM resistance following nanoparticle exposure. Statistical analysis of parameters from an exponential resistance decay model was then used to quantify and analyze differences between the impedance profiles of nanoparticles that were unfunctionalized, amine-functionalized, or carboxyl-functionalized. All of the nanoparticles triggered a decrease in membrane resistance, indicating nanoparticle-induced disruption of the tBLM. Hierarchical clustering allowed the potency of nanoparticles for reducing tBLM resistance to be ranked in the order amine >carboxyl~bare silica. Dynamic light scattering analysis revealed that tBLM exposure triggered minor coalescence for bare and amine-functionalized silica nanoparticles but not for carboxyl-functionalized silica nanoparticles. These results indicate that the tBLM method can reproducibly characterize ENM-induced biomembrane disruption and can distinguish the BLM-disruption patterns of nanoparticles that are identical except for their surface functional groups."
According to the news editors, the research concluded: "The method provides insight into mechanisms of molecular interaction involving biomembranes and is suitable for miniaturization and automation for high-throughput applications to help assess the health risk of nanomaterial exposure or identify ENM having a desired mode of interaction with biomembranes."
For more information on this research see: Biomembrane disruption by silica-core nanoparticles: effect of surface functional group measured using a tethered bilayer lipid membrane. Biochimica Et Biophysica Acta, 2014;1838(1 Pt B):429-37 (see also Biomembranes).
The news editors report that additional information may be obtained by contacting Y. Liu, Dept. of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, United States. Additional authors for this research include Z. Zhang, Q. Zhang, G.L. Baker and R.M Worden.
Keywords for this news article include: Michigan, East Lansing, Biomembranes, Nanoparticle, United States, Bioengineering, Nanotechnology, Emerging Technologies, North and Central America.
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