By a News Reporter-Staff News Editor at Journal of Engineering -- Researchers detail new data in Tissue Engineering. According to news originating from Taoyuan, Taiwan, by VerticalNews correspondents, research stated, "Three-dimensional porous polycaprolactone (PCL) scaffolds with consistent inter-pore channels, 83% porosity and 300-400 mu m pore size were fabricated via selective laser sintering. The PCL scaffold was combined with platelet-rich plasma (PRP) to form a bioactive composite and studied for potential application in bone tissue engineering using porcine adipose-derived stem cells (PASCs)."
Our news journalists obtained a quote from the research from Chang Gung University, "The PCL/PRP/PASCs construct showed enhanced cell seeding efficiency and synergistically increased the differentiation capability of PASCs in osteogenic medium toward the osteoblast lineage, judging from elevated alkaline phosphatase activity and up-regulated osteogenic genes expression. For in vivo study, a 3 cm x 3 cm mandible defect was created in pigs and reconstructed by implanting acellular PCL scaffolds or PCL/PRP/PASCs constructs. Both groups showed new bone formation, however, the new bone volume was 5.1 times higher for PCL/PRP/PASCs 6 months post-operation. The bone density was less and loose in the acellular PCL group and the Young's modulus was only 29% of normal bone. In contrast, continued and compact bone formation was found in PCL/PRP/PASCs and the Young's modulus was 81% that of normal bone."
According to the news editors, the research concluded: "Masson's trichrome stain, immunohistochemical analysis of osteocalcin and collagen type I also confirmed new bone formation."
For more information on this research see: Bone Tissue Engineering with Adipose-Derived Stem Cells in Bioactive Composites of Laser-Sintered Porous Polycaprolactone Scaffolds and Platelet-Rich Plasma. Materials, 2013;6(11):4911-4929. Materials can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Wiley-Blackwell - www.wiley.com/; Materials - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4176)
The news correspondents report that additional information may be obtained from H.T. Liao, Chang Gung University, Dept. of Mech Engn, Tao Yuan 333, Taiwan. Additional authors for this research include J.P. Chen and M.Y. Lee.
Keywords for this news article include: Asia, Taiwan, Taoyuan, Bone-Tissue Engineering
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