By a News Reporter-Staff News Editor at Obesity & Diabetes Week -- Investigators publish new report on Diet and Nutrition Disorders. According to news reporting originating in Hangzhou, People's Republic of China, by NewsRx journalists, research stated, "Pentamethylquercetin (PMQ) is a natural quercetin derivative found in a variety of edible herb. Although PMQ has potential as anti-diabetic agent, there have been no reports on its anti-adipogenic effects in the obese animals."
The news reporters obtained a quote from the research from Zhejiang Chinese Medical University, "This study investigated whether PMQ attenuates high-fat diet (HFD)-induced adipogenesis in the epididymal fat tissues of mice and explored its underlying mechanisms. In comparison with HFD-fed mice, mice fed with PMQ showed significantly lower body weight gain, adipose tissue mass, and plasma levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, and glucose, but higher plasma levels of high-density lipoprotein cholesterol. PMQ significantly reversed the HFD-induced regulation of Sirt1/mTOR signaling genes (Sirt1, mTOR, 4EBP1, and S6K1), and key adipogenic genes (PPAR gamma, SREBP1, FAS, ATGL, HSL, and Perilipin) in the epididymal adipose tissues of obese mice. However, nicotinamide appeared to partly inhibit PMQ-mediated anti-adipogenic effects involved in this attenuation. These results suggested that PMQ inhibited visceral adipogenesis by suppressing the Sirt1-mediated mTOR and adipogenesis signaling cascades."
According to the news reporters, the research concluded: "It might be a potential candidate for the treatment of obesity."
For more information on this research see: Pentamethylquercetin reduces fat deposition via Sirt1-mediated pathways in male obese mice induced by a high fat diet. Food and Chemical Toxicology, 2013;62():463-469. Food and Chemical Toxicology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Food and Chemical Toxicology - www.elsevier.com/wps/product/cws_home/237)
Our news correspondents report that additional information may be obtained by contacting H.Z. Ying, Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, People's Republic of China. Additional authors for this research include J.N. Zang, L.L. Deng, Z.Y. Wang and C.H. Yu (see also Diet and Nutrition Disorders).
Keywords for this news article include: Asia, Obesity, Hangzhou, Diabetes, Genetics, Bariatrics, Cholesterol, Adipogenesis, People's Republic of China, Diet and Nutrition Disorders
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