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Studies Conducted at Konan University on DNA Research Recently Reported

February 25, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on DNA Research are discussed in a new report. According to news reporting out of Hyogo, Japan, by NewsRx editors, research stated, "Pressure is a thermodynamic parameter that can induce structural changes in biomolecules due to a volumetric decrease. Although most proteins are denatured by pressure over 100 MPa because they have the large cavities inside their structures, the double-stranded structure of DNA is stabilized or destabilized only marginally depending on the sequence and salt conditions."

Our news journalists obtained a quote from the research from Konan University, "The thermal stability of the G-quadruplex DNA structure, an important non-canonical structure that likely impacts gene expression in cells, remarkably decreases with increasing pressure. Volumetric analysis revealed that human telomeric DNA changed by more than 50 cm(3) mol(-1) during the transition from a random coil to a quadruplex form. This value is approximately ten times larger than that for duplex DNA under similar conditions. The volumetric analysis also suggested that the formation of G-quadruplex DNA involves significant hydration changes. The presence of a cosolute such as poly(ethylene glycol) largely repressed the pressure effect on the stability of G-quadruplex due to alteration in stabilities of the interactions with hydrating water."

According to the news editors, the research concluded: "This review discusses the importance of local perturbations of pressure on DNA structures involved in regulation of gene expression and highlights the potential for application of high-pressure chemistry in nucleic acid-based nanotechnology."

For more information on this research see: Effect of Pressure on Thermal Stability of G-Quadruplex DNA and Double-Stranded DNA Structures. Molecules, 2013;18(11):13297-13319. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer -; Molecules -

Our news journalists report that additional information may be obtained by contacting S. Takahashi, Konan Univ, Fac Frontiers Innovat Res Sci & Technol FIRST, Chuo Ku, Kobe, Hyogo 6500047, Japan (see also DNA Research).

Keywords for this news article include: Asia, Hyogo, Japan, DNA Research

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Source: Life Science Weekly

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