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Researchers from Wake Forest University School of Medicine Provide Details of New Studies and Findings in the Area of Tissue Engineering

February 26, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Biomedicine and Biomedical Engineering have been presented. According to news reporting out of Winston Salem, North Carolina, by NewsRx editors, research stated, "This review illustrates promising regenerative medicine technologies that are being developed for the treatment of gastrointestinal diseases. The main strategies under validation to bioengineer or regenerate liver, pancreas, or parts of the digestive tract are twofold: engineering of progenitor cells and seeding of cells on supporting scaffold material."

Our news journalists obtained a quote from the research from the Wake Forest University School of Medicine, "In the first case, stem cells are initially expanded under standard tissue culture conditions. Thereafter, these cells may either be delivered directly to the tissue or organ of interest, or they may be loaded onto a synthetic or natural three-dimensional scaffold that is capable of enhancing cell viability and function. The new construct harbouring the cells usually undergoes a maturation phase within a bioreactor. Within the bioreactor, cells are conditioned to adopt a phenotype similar to that displayed in the native organ. The specific nature of the scaffold within the bioreactor is critical for the development of this high-function phenotype. Efforts to bioengineer or regenerate gastrointestinal tract, liver and pancreas have yielded promising results and have demonstrated the immense potential of regenerative medicine."

According to the news editors, the research concluded: "However, a myriad of technical hurdles must be overcome before transplantable, engineered organs become a reality."

For more information on this research see: Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut, 2013;62(5):774-86. (BMJ Publishing Group -; Gut -

Our news journalists report that additional information may be obtained by contacting G. Orlando, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States. Additional authors for this research include J. Dominguez Bendala, T. Shupe, C. Bergman, K.N. Bitar, C. Booth, M. Carbone, K.L. Koch, J.P. Lerut, J.M. Neuberger, B. Petersen, C. Ricordi, A. Atala, R.J. Stratta and S. Soker (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, Technology, Winston Salem, United States, North Carolina, Bioengineering, Gastroenterology, North and Central America.

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Source: Biotech Week

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