News Column

Researchers from Department of Biotechnology Describe Findings in Pseudomonas aeruginosa

February 26, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Proteobacteria are presented in a new report. According to news originating from Noida, India, by NewsRx correspondents, research stated, "Pseudomonas aeruginosa is a gram-negative pathogen that has become an important cause of infection, especially in patients with compromised host defense mechanisms. It is frequently related to nosocomial infections such as pneumonia, urinary tract infections (UTIs) and bacteremia."

Our news journalists obtained a quote from the research from the Department of Biotechnology, "The biofilm formed by the bacteria allows it to adhere to any surface, living or non-living and thus Pseudomonal infections can involve any part of the body. Further, the adaptive and genetic changes of the micro-organisms within the biofilm make them resistant to all known antimicrobial agents making the Pseudomonal infections complicated and life threatening. Pel, Psi and Alg operons present in P. aeruginosa are responsible for the biosynthesis of extracellular polysaccharide which plays an important role in cell cell and cell surface interactions during biofilm formation. Understanding the bacterial virulence which depends on a large number of cell-associated and extracellular factors is essential to know the potential drug targets for future studies."

According to the news editors, the research concluded: "Current novel methods like small molecule based inhibitors, phytochemicals, bacteriophage therapy, photodynamic therapy, antimicrobial peptides, monoclonal antibodies and nanoparticles to curtail the biofilm formed by P. aeruginosa are being discussed in this review."

For more information on this research see: Pseudomonas aeruginosa biofilm: Potential therapeutic targets. Biologicals, 2014;42(1):1-7. Biologicals can be contacted at: Academic Press Ltd- Elsevier Science Ltd, 24-28 Oval Rd, London NW1 7DX, England. (Elsevier - www.elsevier.com; Biologicals - www.elsevier.com/wps/product/cws_home/622793)

The news correspondents report that additional information may be obtained from G. Sharma, Jaypee Inst Informat Technol, Dept. of Biotechnol, Noida 201307, India. Additional authors for this research include S. Rao, A. Bansal, S. Dang, S. Gupta and R. Gabrani (see also Proteobacteria).

Keywords for this news article include: Asia, Antimicrobials, Noida, India, Therapy, Genetics, Pseudomonadaceae, Gammaproteobacteria, Pseudomonas Infections, Pseudomonas aeruginosa, Gram-Negative Aerobic Bacteria, Gram-Negative Bacterial Infections, Gram-Negative Aerobic Rods and Cocci

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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