By a News Reporter-Staff News Editor at Drug Week -- Current study results on Nanofibers have been published. According to news reporting originating in Tartu, Estonia, by NewsRx journalists, research stated, "We showed that scanning white light interferometry (SWLI) can provide nanometer depth resolution in 3D topographic analysis of electrospun drug-loaded nanofibrous mats without sample preparation. The method permits rapidly investigating geometric properties (e.g. fiber diameter, orientation and morphology) and surface topography of drug-loaded nanofibers and nanomats."
The news reporters obtained a quote from the research from the University of Tartu, "Electrospun nanofibers of a model drug, piroxicam (PRX), and hydroxypropyl methylcellulose (HPMC) were imaged. Scanning electron microscopy (SEM) served as a reference method. SWLI 3D images featuring 29 nm by 29 nm active pixel size were obtained of a 55 mu m x 40 mu m area. The thickness of the drug-loaded non-woven nanomats was uniform, ranging from 2.0 mu m to 3.0 mu m (SWLI), and independent of the ratio between HPMC and PRX. The average diameters (n = 100, SEM) for drug-loaded nanofibers were 387 +/- 125 nm (HPMC and PRX 1: 1), 407 +/- 144 nm (HPMC and PRX 1: 2), and 290 +/- 100 nm (HPMC and PRX 1: 4). We found advantages and limitations in both techniques. SWLI permits rapid non-contacting and non-destructive characterization of layer orientation, layer thickness, porosity, and surface morphology of electrospun drug-loaded nanofibers and nanomats."
According to the news reporters, the research concluded: "Such analysis is important because the surface topography affects the performance of nanomats in pharmaceutical and biomedical applications."
For more information on this research see: Nanometer depth resolution in 3D topographic analysis of drug-loaded nanofibrous mats without sample preparation. International Journal of Pharmaceutics, 2014;462(1-2):29-37. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news correspondents report that additional information may be obtained by contacting U. Paaver, University of Tartu, Inst Phys, EE-51014 Tartu, Estonia. Additional authors for this research include J. Heinamaki, I. Kassamakov, E. Haeggstrom, T. Ylitalo, A. Nolvi, J. Kozlova, I. Laidmae, K. Kogermann and P. Veski (see also Nanofibers).
Keywords for this news article include: Tartu, Europe, Estonia, Nanotechnology, Emerging Technologies
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