By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Life Science Research have been presented. According to news reporting from Xi'an, People's Republic of China, by NewsRx journalists, research stated, "Extensive studies have shown that titanium dioxide (TiO2) nanomaterials (NMs) can cause toxicity in vitro and in vivo under normal conditions. However, an adverse effect induced by nano-TiO2 in many diseased conditions, typically characterized by oxidative stress (OS), remains unknown."
The news correspondents obtained a quote from the research from Xi'an Jiao Tong University, "We investigated the toxicity of nano-TiO2 in rat liver cells (BRL-3A) and Sprague-Dawley (SD) rat livers under OS conditions, which were generated using hydrogen peroxide (H2O2) in vitro and alloxan in vivo, respectively. In vitro results showed that cell death ratios after nano-TiO2 exposure were significantly enhanced (up to 2.62-fold) in BRL-3A cells under OS conditions, compared with normal controls. Significant interactions between OS conditions and nano-TiO2 resulted in the rapid G0/G1 to S phase transition and G2/M arrest, which were opposite to G0/G1 phase arrest in cells after NMs exposure only. In vivo results showed that obvious pathological changes in rat livers and the increased activities of four enzymes (i.e. aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and alkaline phosphatase) owing to liver damage after nano-TiO2 exposure under OS conditions, compared with their healthy controls. In addition, compared with increased hepatotoxicity after nano-TiO2 exposure, micro-TiO2 showed no adverse effects to cells and rat livers under OS conditions."
According to the news reporters, the research concluded: "Our results suggested that OS conditions synergistically increase nano-TiO2 induced toxicity in vitro and in vivo, indicating that the evaluation of nanotoxicity under OS conditions is essentially needed prior to various applications of NMs in foods, cosmetics and potential treatment of diseases."
For more information on this research see: Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague-Dawley rats. Journal of Applied Toxicology, 2014;34(4):345-356. Journal of Applied Toxicology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Toxicology - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1263)
Our news journalists report that additional information may be obtained by contacting B.Y. Sha, Xi An Jiao Tong Univ, Sch Thermal Energy & Power Engn, Xian 710049, People's Republic of China. Additional authors for this research include W. Gao, S.Q. Wang, X.C. Gou, W. Li, X. Liang, Z.G. Qu, F. Xu and T.J. Lu (see also Life Science Research).
Keywords for this news article include: Asia, Xi'an, Chemicals, Chemistry, Light Metals, Titanium Dioxide, Life Science Research, People's Republic of China
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