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Reports from York University Highlight Recent Findings in Capillary Electrophoresis

February 25, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Capillary Electrophoresis have been published. According to news reporting from North York, Canada, by NewsRx journalists, research stated, "We describe a mathematical approach that enables extraction of kinetic rate constants from thousands of studies conducted over the past two decades with affinity capillary electrophoresis (ACE). Previously, ACE has been used almost exclusively for obtaining equilibrium constants of intermolecular interactions."

The news correspondents obtained a quote from the research from York University, "In this article, we prove that there exists an analytical solution of partial differential equations describing mass transfer in ACE. By using an in silico study, we demonstrate that the solution is applicable to experimental conditions that are typically used in ACE and found in most historical ACE experiments. The solution was validated by extracting rate constants from previously published ACE data and closely matching independently obtained results. Lastly, it was used to obtain previously unknown rate constants from historical ACE data. The new mathematical approach expands the applicability of ACE to a wider range of biomolecular interactions and enables both prospective and retrospective data analysis."

According to the news reporters, the research concluded: "The obtained kinetic information will be of significant practical value to the fields of pharmacology and molecular biology."

For more information on this research see: Extracting Kinetics from Affinity Capillary Electrophoresis (ACE) Data: A New Blade for the Old Tool. Analytical Chemistry, 2014;86(2):1298-1305. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Analytical Chemistry -

Our news journalists report that additional information may be obtained by contacting M. Kanoatov, York University, Center Res Biomol Interact, North York, ON M3J 1P3, Canada. Additional authors for this research include L.T. Cherney and S.N. Krylov (see also Capillary Electrophoresis).

Keywords for this news article include: Canada, Ontario, North York, North and Central America, Capillary Electrophoresis

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Source: Life Science Weekly

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