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Reports from National Institute of Agrobiological Sciences Add New Data to Findings in Edible Vaccines

February 25, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Biotechnology. According to news originating from Ibaraki, Japan, by NewsRx correspondents, research stated, "Genetic modification (GM) by Agrobacterium-mediated transformation is a robust and widely employed method to confer new traits to crops. In this process, a transfer DNA is delivered into the host genome, but it is still unclear how the host genome is altered by this event at single-base resolution."

Our news journalists obtained a quote from the research from the National Institute of Agrobiological Sciences, "To decipher genomic discrepancy between GM crops and their host, we conducted whole-genome sequencing of a transgenic rice line OSCR11. This rice line expresses a seed-based edible vaccine containing two major pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis. We revealed that genetic differences between OSCR11 and its host a123 were significantly less than those between a123 and its precedent cultivar Koshihikari. The pattern of nucleotide base substitution in OSCR11, relative to a123, was consistent with somaclonal variation. Mutations in OSCR11 probably occurred during the cell culture steps."

According to the news editors, the research concluded: "In addition, strand-specific mRNA-Seq revealed similar transcriptomes of a123 and OSCR11, supporting genomic integrity between them."

For more information on this research see: A whole-genome analysis of a transgenic rice seed-based edible vaccine against cedar pollen allergy. Dna Research, 2013;20(6):623-31. (Oxford University Press -; Dna Research -

The news correspondents report that additional information may be obtained from T. Kawakatsu, 1Genetically Modified Organism Research Center, National Institute of Agrobiological Sciences, 2-1-2 Kan-nondai, Tsukuba, Ibaraki 305-8602, Japan. Additional authors for this research include Y. Kawahara, T. Itoh and F. Takaiwa (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Japan, Pollen, Ibaraki, Flowering Tops, Edible Vaccines, Plant Germ Cells, Plant Structures, Synthetic Vaccines.

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Source: Life Science Weekly

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