News Column

Reports from H.J. Lee et al Highlight Recent Findings in Enzymes and Coenzymes

February 25, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Enzymes and Coenzymes is now available. According to news reporting out of Suwon, South Korea, by NewsRx editors, research stated, "Nanoparticles have been widely used for delivering various chemical and biomolecular drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles have advantages of non-cytotoxicity and biodegradability."

Our news journalists obtained a quote from the research, "In this study, a recombinant 30Kc19 protein was applied to human serum albumin (HSA) nanoparticles to enhance cellular uptake and stability of a nanoparticle cargo enzyme. The 30Kc19 protein, which originates from silkworm, has cell-penetrating and enzymestabilizing abilities. Therefore, 30Kc19-HSA nanoparticles were expected to enhance cellular uptake and stability of an enzyme loaded on the nanoparticles. Here, nanoparticles loaded with beta-galactosidase were prepared using the desolvation method. The 30Kc19-HSA nanoparticles were uniformly spherical in shape, dispersed evenly in phosphate buffered saline and cell culture media, and released beta-galactosidase in a sustained manner. The 30Kc19-HSA nanoparticles had negligible toxicity to animal cells and exhibited enhanced cellular uptake and intracellular stability of beta-galactosidase in HeLa and HEK293 cells when compared with those of HSA nanoparticles."

According to the news editors, the research concluded: "These results suggest that 30Kc19-HSA protein nanoparticles could be used as a versatile tool for drug delivery to various cells."

For more information on this research see: Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles. Biomaterials, 2014;35(5):1696-1704. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting H.J. Lee, Adv Inst Convergence Technol, Suwon 443270, South Korea. Additional authors for this research include H.H. Park, J.A. Kim, J.H. Park, J. Ryu, J. Choi, J. Lee, W.J. Rhee and T.H. Park (see also Enzymes and Coenzymes).

Keywords for this news article include: Asia, Suwon, South Korea, Nanoparticle, Serum Albumin, Blood Proteins, Nanotechnology, beta-Galactosidase, Acute-Phase Proteins, Glycoside Hydrolases, Emerging Technologies, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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