Our news journalists obtained a quote from the research, "In this study, a recombinant 30Kc19 protein was applied to human serum albumin (HSA) nanoparticles to enhance cellular uptake and stability of a nanoparticle cargo enzyme. The 30Kc19 protein, which originates from silkworm, has cell-penetrating and enzymestabilizing abilities. Therefore, 30Kc19-HSA nanoparticles were expected to enhance cellular uptake and stability of an enzyme loaded on the nanoparticles. Here, nanoparticles loaded with beta-galactosidase were prepared using the desolvation method. The 30Kc19-HSA nanoparticles were uniformly spherical in shape, dispersed evenly in phosphate buffered saline and cell culture media, and released beta-galactosidase in a sustained manner. The 30Kc19-HSA nanoparticles had negligible toxicity to animal cells and exhibited enhanced cellular uptake and intracellular stability of beta-galactosidase in HeLa and HEK293 cells when compared with those of HSA nanoparticles."
According to the news editors, the research concluded: "These results suggest that 30Kc19-HSA protein nanoparticles could be used as a versatile tool for drug delivery to various cells."
For more information on this research see: Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles. Biomaterials, 2014;35(5):1696-1704. Biomaterials can be contacted at:
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