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New Xenografts Data Have Been Reported by Researchers at Tokai University

February 26, 2014

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Biotechnology is now available. According to news originating from Kanagawa, Japan, by NewsRx correspondents, research stated, "The interaction between transplanted cells and host tissues is important for the growth and maintenance of transplanted cells. To analyze the mechanisms of these interactions, a systemic fluorescent protein-expressing mouse is a useful recipient."

Our news journalists obtained a quote from the research from Tokai University, "In this study, we generated a novel NOG strain, which strongly expresses enhanced green fluorescent protein (EGFP; PgkEGFP-NOG), especially in the liver, kidney, gastrointestinal tract, and testis. Because the host tissues expressed EGFP, xenotransplanted human cancer cells were clearly identified as EGFP-negative colonies in PgkEGFP-NOG mice. Immunohistochemical analysis revealed that EGFP-expressing stromal tissues formed a complicated tumor microenvironment within xenograft tissues. Moreover, a similar microenvironment was observed in human iPS cell-derived teratomas."

According to the news editors, the research concluded: "Collectively, these results indicated that a suitable microenvironment is essential for the growth and maintenance of xenotransplanted cells and that PgkEGFP-NOG mice represent a useful animal model for analyzing the mechanisms of microenvironment formation."

For more information on this research see: A Novel Enhanced Green Fluorescent Protein-Expressing NOG Mouse for Analyzing the Microenvironment of Xenograft Tissues. Experimental Animals, 2014;63(1):55-62. Experimental Animals can be contacted at: Int Press Editing Centre Inc, 1-2-3 Sugamo, Toshima-Ku, Tokyo, 170 0002, Japan (see also Biotechnology).

The news correspondents report that additional information may be obtained from Y. Higuchi, Tokai University, Sch Med, Dept. of Pathol & Regenerat Med, Isehara, Kanagawa 2591193, Japan. Additional authors for this research include K. Kawai, M. Yamamoto, M. Kuronuma, Y. Ando, I. Katano, M. Nakamura and H. Suemizu.

Keywords for this news article include: Asia, Biotechnology, Japan, Kanagawa, Xenograft, Xenotransplantion, Luminescent Proteins, Green Fluorescent Proteins

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Source: Biotech Week

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