News Column

New Peroxidases Findings from Southwest University Reported

February 25, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Enzymes and Coenzymes is now available. According to news reporting originating in Chongqing, People's Republic of China, by NewsRx journalists, research stated, "In this paper, a novel dual signal amplification strategy was proposed based on hollow platinum nanoparticles decorated Fe3O4 nanoparticles (HPtNPs-Fe3O4) and glucose oxidase (GOD) for sensitive detection of alpha-1-fetoprotein (AFP). In such system, HPtNPs-Fe3O4 couples with glucose oxidase to form a pseudobienzymatic system because both HPtNPs and Fe3O4 nanoparticles (NPs) have peroxidase-like catalytic activity and this peroxidase mimetic is more stable and economical than natural peroxidases."

The news reporters obtained a quote from the research from Southwest University, "With the employment of bovine serum albumin (BSA), the biocompatibility, stability and water solubility of Fe3O4 NPs was further enhanced. The BSA functionalized Fe3O4 NPs provided lysine groups to immobilized HPtNPs, antibodies and GOD, which further amplified the detection signal. The results show that the sensor exhibited attractive redox electrochemical activity and high catalysis activity when detected in the working buffer containing 3.6 mM D-glucose."

According to the news reporters, the research concluded: "The electrochemical immunosensor exhibited a linear range of 0.01-60 ng/mL with a low detection limit of 1.6 pg/mL."

For more information on this research see: Hollow platinum decorated Fe3O4 nanoparticles as peroxidase mimetic couple with glucose oxidase for pseudobienzyme electrochemical immunosensor. Sensors and Actuators B-Chemical, 2014;193():461-466. Sensors and Actuators B-Chemical can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Enzymes and Coenzymes).

Our news correspondents report that additional information may be obtained by contacting Z.H. Yang, Southwest University, Key Lab Luminescence & Real Time Anal, Chongqing 400715, People's Republic of China. Additional authors for this research include Y.Q. Chai, R. Yuan, Y. Zhuo, Y. Li, J. Han and N. Liao.

Keywords for this news article include: Asia, Chongqing, Chemistry, Peroxidases, Nanoparticle, Nanotechnology, Electrochemical, Glucose Oxidase, Emerging Technologies, Enzymes and Coenzymes, Alcohol Oxidoreductases, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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