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New Findings on Trimethyl Ammonium Compounds from East China Normal University Summarized

February 25, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Trimethyl Ammonium Compounds is the subject of a report. According to news reporting originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "In this work, we report the development of a highly sensitive and stable choline/acetylcholine sensor based on the synergetic effect of multi-walled carbon nanotubes and ZnO nanoparticles. This unique multi-layer structure provided a favorable microenvironment to maintain the bioactivity of choline oxidase and acetylcholinesterase, which led to a rapid amperometric response to choline and acetylcholine."

Our news editors obtained a quote from the research from East China Normal University, "This nanomaterials-based choline/acetylcholine sensor was highly sensitive and showed good stability over a relatively long-term storage (90 days). The sensor prepared by loading 1.0-unit choline oxidase and acetylcholinesterase showed a linear response range of 1.0 mu M to 0.8 mM and 1.0 mu M to 1.0 mM, a sensitivity of 178 mu A mM(-1) cm(-2) and 180 mu A mM(-1) cm(-2), and a detection limit of 0.3 mu M, respectively."

According to the news editors, the research concluded: "The sensor prepared was used to detect choline in human blood plasma samples, and the obtained results were consistent with those of the HPLC-MS/MS assay."

For more information on this research see: Improved enzyme immobilization for enhanced bioelectrocatalytic activity of choline sensor and acetylcholine sensor. Sensors and Actuators B-Chemical, 2014;193():904-910. Sensors and Actuators B-Chemical can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Trimethyl Ammonium Compounds).

The news editors report that additional information may be obtained by contacting L.T. Zhang, E China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, People's Republic of China. Additional authors for this research include J. Chen, Y.T. Wang, L. Yu, J. Wang, H. Peng and J.Z. Zhu.

Keywords for this news article include: Asia, Shanghai, Acetylcholine, Ethanolamines, Biogenic Amines, People's Republic of China, Trimethyl Ammonium Compounds, Quaternary Ammonium Compounds

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Source: Life Science Weekly

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