By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Proteomics have been published. According to news originating from Milan, Italy, by NewsRx correspondents, research stated, "The stimulation of fibroblast growth factor receptors (FGFRs) with distinct FGF ligands generates specific cellular responses. However, the mechanisms underlying this paradigm have remained elusive."
Our news journalists obtained a quote from the research from the European Institute of Oncology, "Here, we show that FGF-7 stimulation leads to FGFR2b degradation and, ultimately, cell proliferation, whereas FGF-10 promotes receptor recycling and cell migration. By combining mass-spectrometry-based quantitative proteomics with fluorescence microscopy and biochemical methods, we find that FGF-10 specifically induces the rapid phosphorylation of tyrosine (Y) 734 on FGFR2b, which leads to PI3K and SH3BP4 recruitment. This complex is crucial for FGFR2b recycling and responses, given that FGF-10 stimulation of either FGFR2b_Y734F mutant-or SH3BP4-depleted cells switches the receptor endocytic route to degradation, resulting in decreased breast cancer cell migration and the inhibition of epithelial branching in mouse lung explants."
According to the news editors, the research concluded: "Altogether, these results identify an intriguing ligand-dependent mechanism for the control of receptor fate and cellular outputs that may explain the pathogenic role of deregulated FGFR2b, thus offering therapeutic opportunities."
For more information on this research see: Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs. Molecular Cell, 2013;51(6):707-722. Molecular Cell can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier - www.elsevier.com; Molecular Cell - www.elsevier.com/wps/product/cws_home/621184)
The news correspondents report that additional information may be obtained from C. Francavilla, European Inst Oncol, Mol Med Program, I-20141 Milan, Italy. Additional authors for this research include K.T.G. Rigbolt, K.B. Emdal, G. Carraro, E. Vernet, D.B. Bekker-Jensen, W. Streicher, M. Wikstrom, M. Sundstrom, S. Bellusci, U. Cavallaro, B. Blagoev and J.V. Olsen (see also Proteomics).
Keywords for this news article include: Milan, Italy, Europe, Proteomics, Nanotechnology, Molecular Switches, Emerging Technologies
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