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Findings on Nanoparticles Detailed by Investigators at Seoul National University

February 25, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting originating in Suwon, South Korea, by NewsRx journalists, research stated, "It is predicted that the toxicity of nanoparticles may be different depending on the properties of the nanoparticles and biological system being tested. However, the factors that influence the toxicity of nanoparticles have not been adequately investigated."

The news reporters obtained a quote from the research from Seoul National University, "In this study, we characterized two types of TiO2 nanorods, anatase (ATO) and brookite (BTO), and compared their toxicity in vivo and in vitro. ATO and BTO differed from each other most notably in their surface areas. Treatment with the two TiO2 nanorods (10 mu g ml(-1)) produced similar effects on the cell cycle in eight cell lines which are derived from potential target organs of nanoparticles, with the BTO eliciting stronger responses than ATO in all cell lines, among the cell lines, H9C2 showed the maximal change. Similarly, when mice were exposed to two TiO2 nanorods (1 mg kg(-1)), BTO induced clearer histopathological lesions and triggered a more robust secretion of inflammatory cytokines than ATO. Furthermore, we compared the cellular response of both TiO2 nanorods using BEAS-2B cells, the human bronchial epithelial cell line. Both nanorods induced cell death by increasing the formation of autophagosome-like vacuoles. The mitochondrial calcium concentration decreased by exposure of both types, but the distribution of lysosome and endoplasmic reticulum (ER) showed a clear difference between the two nanorods. Thus, we conclude that the surface area acts as an important factor which depends on toxicity of nanorod type-TiO2 nanoparticles."

According to the news reporters, the research concluded: "Furthermore, the toxicity of nanoparticles varies according to the type of cells tested, and that the assembly of autophagosome-like vacuoles is a critical part of the cellular response to nanoparticle exposure."

For more information on this research see: Comparison of toxicity of different nanorod-type TiO2 polymorphs in vivo and in vitro. Journal of Applied Toxicology, 2014;34(4):357-366. Journal of Applied Toxicology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Journal of Applied Toxicology -

Our news correspondents report that additional information may be obtained by contacting E.J. Park, Seoul National University, Adv Inst Convergence Technol, Suwon 443270, South Korea. Additional authors for this research include G.H. Lee, H.W. Shim, J.H. Kim, M.H. Cho and D.W. Kim (see also Nanoparticles).

Keywords for this news article include: Asia, Suwon, South Korea, Nanotechnology, Emerging Technologies

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Source: Life Science Weekly

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