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Findings on Coenzymes Detailed by Investigators at University of Alberta

February 28, 2014



By a News Reporter-Staff News Editor at Drug Week -- Research findings on Enzymes and Coenzymes are discussed in a new report. According to news originating from Edmonton, Canada, by NewsRx correspondents, research stated, "Optical fluidic microcavities exhibit many attractive properties for the development of a sensitive, label-free biosensor. They can be inexpensive, non-toxic, reusable, and sensitive to low analyte concentrations, making them candidates for integration into Lab-on-a-Chip (LoC) devices."

Our news journalists obtained a quote from the research from the University of Alberta, "Here, a fluorescent-core microcapillary (FCM) sensor is demonstrated. It utilizes the whispering gallery mode (WGM) resonances in the fluorescence spectrum of a silicon quantum-dot-coated microcapillary channel. Well-defined WGMs with a visibility of 0.37 and Q-factors up to 700 were observed. The FCMs showed refractometric sensitivities of 10-20 nm/RIU for methanol, ethanol, and sucrose solutions, and detection limits approaching 10(-4) RIU. The FCMs were then functionalized for biotin and streptavidin detection, in order to demonstrate the feasibility of this microfluidic device for biosensing applications. Biotin molecules were immobilized on the inner surface of the FCMs using an aminopropyltrimethoxysilane linker. Buffer solutions were then pumped through the capillary channel and the fluorescence spectrum was monitored. Resonance shifts on the order of tens of pm were detected after the binding of biotin, and after the subsequent attachment of streptavidin molecules to the biotinylated surface."

According to the news editors, the research concluded: "Nonspecific streptavidin binding remains a significant problem."

For more information on this research see: Feasibility of a Fluorescent-Core Microcapillary for Biosensing Applications. Sensor Letters, 2013;11(8):1513-1518. Sensor Letters can be contacted at: Amer Scientific Publishers, 26650 The Old Rd, Ste 208, Valencia, CA 91381-0751, USA. (American Scientific Publishers - www.aspbs.com/)

The news correspondents report that additional information may be obtained from S. McFarlane, University of Alberta, Dept. of Chem, Edmonton, AB T6G 2G2, Canada. Additional authors for this research include C.P.K. Manchee, J.W. Silverstone, J.G.C. Veinot and A. Meldrum (see also Enzymes and Coenzymes).

Keywords for this news article include: Canada, Biotin, Alberta, Edmonton, Streptavidin, Micronutrient, Bacterial Proteins, Diet and Nutrition, Enzymes and Coenzymes, North and Central America

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Source: Drug Week


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