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Findings from Shanghai Jiao-Tong University Provides New Data about DNA Research

February 25, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in DNA Research. According to news reporting originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Chirality is widely found in nature and is expressed hierarchically in many organic-inorganic hybrid materials. Optical activity (OA) is the most fundamental attribute of these chiral materials."

Our news editors obtained a quote from the research from Shanghai Jiao-Tong University, "In this study, we found that the OA of impeller-like chiral DNA-silica assemblies (CDSAs) was inverted with the addition of water. The state of DNA under dry and wet conditions, and the dual chirality of chiral DNA layers and twisted helical arrays of opposite handedness in CDSAs were considered to exert predominant effects on the OAs. The circular dichroism (CD) responses for the dry CDSAs were mostly attributed to the chiral arrangement of DNA layers, whereas the opposite CD responses for the wet CDSAs primarily originated from twisted helical arrays of DNA molecules. The observed CD signals were a super-position of the two opposing OA responses. The increase in the longitudinal relation of DNA molecules due to the recovery of a double-helical structure of DNA in the presence of water was considered to be the reason for the increase in intensity of the CD signals that originated from the twisted helical array, which led to the inversion of OA of the CDSAs. The inversion of the plasmon-resonance-based OAs for the chiral-arranged achiral Ag nanoparticles (NPs) located in the channels of the CDSAs in dry and wet states further confirmed the dual chirality of DNA packing."

According to the news editors, the research concluded: "Such research on DNA assemblies and metal NPs with dual, opposite chirality assists in the understanding of DNA hierarchical chirality in living systems and the creation of macroscopic ordered helical materials and biosensors."

For more information on this research see: Water-Dependent Optical Activity Inversion of Chiral DNA-Silica Assemblies. Chemistry-A European Journal, 2013;19(48):16382-16388. Chemistry-A European Journal can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany (see also DNA Research).

The news editors report that additional information may be obtained by contacting B. Liu, Shanghai Jiao Tong University, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Shanghai 200240, People's Republic of China. Additional authors for this research include Y.Y. Cao, Y.Y. Duan and S.A. Che.

Keywords for this news article include: Asia, Shanghai, DNA Research, People's Republic of China

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Source: Life Science Weekly

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