Iranian researchers have designed and produced a new SPION-C595 contrast agent to take targeted magnetic resonance molecular images of ovarian cancer cells.
Dr. Dariush Shahbazi Gahrouie, professor of medical physics in
"Magnetic nanoprobe, which is super paramagnetic iron oxide nanoparticles (SPIONs-C959), bonded with folic acid, was produced," he said.
"In this research, the new contrast agent (SPIONs-C595) was introduced, designed and produced to detect and take images from ovarian cancer cells."
The compound was first prepared and then toxicity and quality control tests were carried out, including studying hydrodynamic size changes of particles, magnetic properties and resting time. The performance of the nanoprobe was studied in its ability to be attached to cancerous cells under in-vivo and in-vitro conditions by taking MRI images, and the changes in the strength of imaging signal were also investigated.
Gahrouie noted that the produced compound had the desirable stability and biocompatibility in in-vitro condition, to the extent that in the majority of concentrations and test times, the life duration of cells was reported to be higher than 80 percent.
Resting time tests and concentration of iron at the level of ovarian cancer cells and MRI images taken after the incubation of the cells with the synthesized nanoprobe and the commercial nanoparticles used in this study indicated much higher tendency of the attachment of the produced compound with the cellular level with high expression of C595 antigen.
Although the performance of nanoprobe was less than what was expected under in-vitro conditions, in-vivo experiments confirm the higher tendency of the product for staying in tumor tissue compared with the commercial nanoparticles used in the research
New contrast agent helps detect ovarian cancer cells
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